Antimicrobial resistance profiles and characterization of Escherichia coli strains from cases of neonatal diarrhea in Spanish pig farms
Visualitza/Obre
Autor/a
Vidal, Anna
Aguirre, Laia
Seminati, Chiara
Tello, Montse
Redondo, Noelia
Martín, Marga
Darwich, Laila
Data de publicació
2020-04-21ISSN
2306-7381
Resum
Escherichia coli is considered one of the most common agents associated with neonatal diarrhea in piglets. The aim of this work was to characterize the pathogenic and antimicrobial resistance (AMR) profiles of 122 E. coli strains isolated from pigs suffering diarrhea (n = 94) and pigs without diarrhea (n = 28) of 24 farms in Spain. Virulence factors, toxins and AMR (ESBL and colistin) genes and AMR phenotypes of E. coli isolates were analyzed. Low prevalence of pathogenic E. coli strains (26%) was found in both groups. However, ETEC and VTEC strains were more frequently isolated from diarrheic piglets. Irrespectively of diarrhea occurrence, 97.5% of the strains showed a multidrug-resistance (MDR) profile to aminopenicillins, sulfonamides and tetracyclines. It was found that 22% of E. coli was CTX-M+, with CTX-M-14 being the principal allelic variant. Remarkably, 81.5% of CTX-M+ strains were isolated from diarrheic animals and presented an extended MDR profile to aminopenicillins, quinolones and aminoglycosides. Finally, low frequencies of colistin resistance genes mcr-1 (4/122) and mcr-4 (1/122) were found. MDR E. coli strains are circulating in pig farms of Spain, representing a serious threat to animal and public health. More appropriate diagnostic approaches (genetic and AMR phenotypic analysis) should be implemented in animal health to optimize antibiotic treatments.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
619 - Veterinària
Pàgines
12
Publicat per
MDPI
Publicat a
Veterinary Sciences
Citació
Vidal, Anna, Laia Aguirre, Chiara Seminati, Montse Tello, Noelia Redondo, Marga Martín, and Laila Darwich. 2020. "Antimicrobial Resistance Profiles And Characterization Of Escherichia Coli Strains From Cases Of Neonatal Diarrhea In Spanish Pig Farms". Veterinary Sciences 7 (2): 48. MDPI AG. doi:10.3390/vetsci7020048.
Programa
Sanitat Animal
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