Porcine circovirus 2 (PCV-2) genetic variability under natural infection scenario reveals a complex network of viral quasispecies
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Fecha de publicación
2018-10-19ISSN
2045-2322
Resumen
Porcine circovirus 2 (PCV-2) is a virus characterized by a high evolutionary rate, promoting the potential
emergence of diferent genotypes and strains. Despite the likely relevance in the emergence of new
PCV-2 variants, the subtle evolutionary patterns of PCV-2 at the individual-host level or over short
transmission chains are still largely unknown. This study aimed to analyze the within-host genetic
variability of PCV-2 subpopulations to unravel the forces driving PCV-2 evolution. A longitudinal weekly
sampling was conducted on individual animals located in three farms after the frst PCV-2 detection. The
analysis of polymorphisms evaluated throughout the full PCV-2 genome demonstrated the presence
of several single nucleotide polymorphisms (SNPs) especially in the genome region encoding for the
capsid gene. The global haplotype reconstruction allowed inferring the virus transmission network
over time, suggesting a relevant within-farm circulation. Evidences of co-infection and recombination
involving multiple PCV-2 genotypes were found after mixing with pigs originating from other sources.
The present study demonstrates the remarkable within-host genetic variability of PCV-2 quasispecies,
suggesting the role of the natural selection induced by the host immune response in driving PCV-2
evolution. Moreover, the efect of pig management in multiple genotype coinfections occurrence and
recombination likelihood was demonstrated.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
English
Materias (CDU)
619 - Veterinaria
Páginas
11
Publicado por
Nature Research
Publicado en
Scientific Reports
Citación
Correa-Fiz, Florencia, Giovanni Franzo, Anna Llorens, Joaquim Segalés, and Tuija Kekarainen. 2018. "Porcine Circovirus 2 (PCV-2) Genetic Variability Under Natural Infection Scenario Reveals A Complex Network Of Viral Quasispecies". Scientific Reports 8 (1). Springer Nature. doi:10.1038/s41598-018-33849-2.
Program
Sanitat Animal
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