Repurposing bioenergetic modulators against protozoan parasites responsible for tropical diseases
Autor/a
Martínez-Flórez, Alba
Galizzi, Melina
Izquierdo, Luis
Bustamante, Juan M.
Rodriguez, Ana
Rodríguez-Cortés, Alhelí
Alberola, Jordi
Fecha de publicación
2020-07-22ISSN
2211-3207
Resumen
Malaria, leishmaniasis and trypanosomiasis are arthropod-borne, parasitic diseases that constitute a major global health problem. They are generally found in developing countries, where lack of access to preventive tools and treatment hinders their management. Because these parasites share an increased demand on glucose consumption with most cancer cells, six compounds used in anti-tumoral research were selected to be tested as antiparasitic agents in in vitro models of Leishmania infantum, Trypanosoma brucei, T. cruzi, and Plasmodium falciparum: dichloroacetic acid (DCA), 3-bromopyruvic acid (3BP), 2-deoxy-D-glucose (2DG), lonidamine (LND), metformin (MET), and sirolimus (SIR). No parasite-killing activity was found in L. infantum promastigotes, whereas DCA and 3BP reduced the burden of intra-macrophagic amastigotes. For T. brucei all selected compounds, but 2DG, decreased parasite survival. DCA, 2DG, LND and MET showed parasite-killing activity in T. cruzi. Finally, anti-plasmodial activity was found for DCA, 2DG, LND, MET and SIR. These results reinforce the hypothesis that drugs with proven efficacy in the treatment of cancer by interfering with ATP production, proliferation, and survival cell strategies might be useful in treating threatening parasitic diseases and provide new opportunities for their repurposing.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
619 - Veterinaria
Páginas
11
Publicado por
Elsevier
Publicado en
International Journal for Parasitology: Drugs and Drug Resistance
Citación
Martínez-Flórez, Alba, Melina Galizzi, Luis Izquierdo, Juan M. Bustamante, Ana Rodriguez, Fernando Rodriguez, Alhelí Rodríguez-Cortés, and Jordi Alberola. 2020. "Repurposing Bioenergetic Modulators Against Protozoan Parasites Responsible For Tropical Diseases". International Journal For Parasitology: Drugs And Drug Resistance 14: 17-27. doi:10.1016/j.ijpddr.2020.07.002.
Program
Sanitat Animal
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