Genome-wide association study for feed efficiency in collective cage-raised rabbits under full and restricted feeding
Visualitza/Obre
Autor/a
Sánchez, J. P.
Legarra, A.
Velasco‐Galilea, M.
Piles, M.
Sánchez, A.
Rafel, O.
González‐Rodríguez, O.
Ballester, M.
Data de publicació
2020-07-22ISSN
0268-9146
Resum
Feed efficiency (FE) is one of the most economically and environmentally relevant traits in the animal production sector. The objective of this study was to gain knowledge about the genetic control of FE in rabbits. To this end, GWASs were conducted for individual growth under two feeding regimes (full feeding and restricted) and FE traits collected from cage groups, using 114 604 autosome SNPs segregating in 438 rabbits. Two different models were implemented: (1) an animal model with a linear regression on each SNP allele for growth trait; and (2) a two‐trait animal model, jointly fitting the performance trait and each SNP allele content, for FE traits. This last modeling strategy is a new tool applied to GWAS and allows information to be considered from non‐genotyped individuals whose contribution is relevant in the group average traits. A total of 189 SNPs in 17 chromosomal regions were declared to be significantly associated with any of the five analyzed traits at a chromosome‐wide level. In 12 of these regions, 20 candidate genes were proposed to explain the variation of the analyzed traits, including genes such as FTO, NDUFAF6 and CEBPA previously associated with growth and FE traits in monogastric species. Candidate genes associated with behavioral patterns were also identified. Overall, our results can be considered as the foundation for future functional research to unravel the actual causal mutations regulating growth and FE in rabbits.
Tipus de document
Article
Versió del document
Versió publicada
Llengua
Anglès
Matèries (CDU)
636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèstics
Pàgines
12
Publicat per
Wiley
Publicat a
Animal Genetics
Citació
Sánchez, J. P., A. Legarra, M. Velasco‐Galilea, M. Piles, A. Sánchez, O. Rafel, O. González‐Rodríguez, and M. Ballester. 2020. "Genome‐Wide Association Study For Feed Efficiency In Collective Cage‐Raised Rabbits Under Full And Restricted Feeding". Animal Genetics 51 (5): 799-810. doi:10.1111/age.12988.
Número de l'acord de la subvenció
EC/H2020/633531/EU/Adapting the feed, the animal and the feeding techniques to improve the efficiency and sustainability of monogastric livestock production systems/Feed-a-Gene
MINECO/Programa Estatal de I+D+I orientada a los Retos de la Sociedad/RTA2014-00015-C02-01/ES/Mejora de la eficiencia alimentaria en cerdos y conejos. Determinismo genético y estrategias de selección/
INIA/Programa Nacional de Proyectos de Investigación Fundamental/RTA2011-00064-00-00/ES/Mejora genética de la eficacia alimentaria en especies prolíficas/
MICIU/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTI2018-097610-R-I00/ES/MEJORA DE LA EFECTIVIDAD Y LA VIABILIDAD DE LOS PROGRAMAS DE SELECCION GENETICA PARA AUMENTAR LA EFICIENCIA ALIMENTARIA DE ESPECIES PROLIFICA/
MINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC‑2013‑12573/ES/ /
Programa
Genètica i Millora Animal
Aquest element apareix en la col·lecció o col·leccions següent(s)
- ARTICLES CIENTÍFICS [2510]
Els següents fitxers sobre la llicència estan associats a aquest element:
Excepte que s'indiqui una altra cosa, la llicència de l'ítem es descriu com http://creativecommons.org/licenses/by/4.0/