Browsing by Author "Abad, Daniel"

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    • Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19 

      Varona, Jose F.; Landete, Pedro; Lopez-Martin, Jose A.; Estrada, Vicente; Paredes, Roger; Guisado-Vasco, Pablo; Fernandez de Orueta, Lucia; Torralba, Miguel; Fortun, Jesus; Vates, Roberto; Barberan, Jose; Clotet, Bonaventura; Ancochea, Julio; Carnevali, Daniel; Cabello, Noemi; Porras, Lourdes; Gijon, Paloma; Monereo, Alfonso; Abad, Daniel; Zuñiga, Sonia; Sola, Isabel; Rodon, Jordi; Vergara-Alert, Julia; Izquierdo-Useros, Nuria; Fudio, Salvador; Pontes, Maria Jose; de Rivas, Beatriz; Giron de Velasco, Patricia; Nieto, Antonio; Gomez, Javier; Aviles, Pablo; Lubomirov, Rubin; Belgrano, Alvaro; Sopesen, Belen; White, Kris M.; Rosales, Romel; Yildiz, Soner; Reuschl, Ann-Kathrin; Thorne, Lucy G.; Jolly, Clare; Towers, Greg J.; Zuliani-Alvarez, Lorena; Bouhaddou, Mehdi; Obernier, Kirsten; McGovern, Briana L.; Rodriguez, M. Luis; Enjuanes, Luis; Fernandez-Sousa, Jose M.; Krogan, Nevan J.; Jimeno, Jose M.; Garcia-Sastre, Adolfo (Life Science Alliance, 2022-01-10) Sanitat Animal
      Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that ...