Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis
Autor/a
Arrieta-Villegas, Claudia
Allepuz, Alberto
Grasa, Miriam
Martín, Maite
Cervera, Zoraida
Mercader, Irene
López-Soria, Sergio
Domingo, Mariano
Fecha de publicación
2020-11-23ISSN
2045-2322
Resumen
Vaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated with BCG and all replacement goat kids were also systematically vaccinated throughout the trial. All animals were tested by Interferon-gamma release assay (IGRA) using vaccine compatible reagents at months 6, 12, 24, and 36. The risk factors for TB infection were also evaluated. At the end of the study, four out of five farms showed variable reductions of the initial prevalence (93.5%, 28.5%, 23.2%, and 14.3% respectively), and an overall incidence reduction of 50% was observed in BCG vaccinated goats, although adult vaccinated goats showed higher incidences than vaccinated goat kids. The unvaccinated positive animals remaining in herds and adult BCG vaccinated goats significantly enhanced the risk of infection in vaccinated animals. A systematic vaccination of goats with BCG, together with the removal of positive unvaccinated animals, may contribute to reducing the TB prevalence in goat herds.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
619 - Veterinaria
Páginas
12
Publicado por
Nature Research
Publicado en
Scientific Reports
Citación
Arrieta-Villegas, Claudia, Alberto Allepuz, Miriam Grasa, Maite Martín, Zoraida Cervera, Irene Mercader, Sergio López-Soria, Mariano Domingo, and Bernat Pérez de Val. 2020. "Long-Term Efficacy Of BCG Vaccination In Goat Herds With A High Prevalence Of Tuberculosis". Scientific Reports 10 (1). doi:10.1038/s41598-020-77334-1.
Número del acuerdo de la subvención
INIA-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTA2015-00043-C02-00/ES/Diagnóstico, vacunación y nuevas herramientas de lucha frente a la tuberculosis en la especie caprina/DVNHLF
Program
Sanitat Animal
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