Browsing PUBLICACIONS CIENTÍFIQUES by Author "Valencia, Alfonso"

Now showing items 1-10 of 10

    • Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection 

      Pradenas, Edwards; Trinité, Benjamin; Urrea, Víctor; Marfil, Silvia; Tarrés-Freixas, Ferran; Ortiz, Raquel; Rovirosa, Carla; Rodon, Jordi; Vergara-Alert, Júlia; Segalés, Joaquim; Guallar, Victor; Valencia, Alfonso; Izquierdo-Useros, Nuria; Noguera-Julian, Marc; Carrillo, Jorge; Paredes, Roger; Mateu, Lourdes; Chamorro, Anna; Toledo, Ruth; Massanella, Marta; Clotet, Bonaventura; Blanco, Julià (Cell Reports Medicine, 2022-01-24) Sanitat Animal
      To understand the determinants of long-term immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the concurrent impact of vaccination and emerging variants, we follow a ...

    • Detection of SARS-CoV-2 in a cat owned by a COVID-19−affected patient in Spain 

      Segalés, Joaquim; Puig, Mariona; Rodon, Jordi; Avila-Nieto, Carlos; Carrillo, Jorge; Cantero, Guillermo; Terrón, Maria Teresa; Cruz, Sílvia; Parera, Mariona; Noguera-Julián, Marc; Izquierdo-Useros, Nuria; Guallar, Víctor; Vidal, Enric; Valencia, Alfonso; Blanco, Ignacio; Blanco, Julià; Clotet, Bonaventura; Vergara-Alert, Júlia (Proceedings of the National Academy of Sciences (PNAS), 2020-09-18) Sanitat Animal
      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is considered a zoonotic pathogen mainly transmitted human to human. Few reports indicate that pets may ...

    • Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice 

      Tarrés-Freixas, Ferran; Trinité, Benjamin; Pons-Grífols, Anna; Romero-Durana, Miguel; Riveira-Muñoz, Eva; Ávila-Nieto, Carlos; Pérez, Mónica; Garcia-Vidal, Edurne; Perez-Zsolt, Daniel; Muñoz-Basagoiti, Jordana; Raïch-Regué, Dàlia; Izquierdo-Useros, Nuria; Andrés, Cristina; Antón, Andrés; Pumarola, Tomàs; Blanco, Ignacio; Noguera-Julián, Marc; Guallar, Victor; Lepore, Rosalba; Valencia, Alfonso; Urrea, Victor; Vergara-Alert, Júlia; Clotet, Bonaventura; Ballana, Ester; Carrillo, Jorge; Segalés, Joaquim; Blanco, Julià (Frontiers in Microbiology, 2022-05-04) Sanitat Animal
      The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced transmissibility, more severity and/or immune evasion; however, the pathogenesis of these new VOCs in experimental SARS-CoV-2 ...

    • Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen 

      Rodon, Jordi; Muñoz-Basagoit, Jordana; Perez-Zsolt, Daniel; Noguera-Julian, Marc; Paredes, Roger; Mateu, Lourdes; Quiñones, Carles; Perez, Carles; Erkizia, Itziar; Blanco, Ignacio; Valencia, Alfonso; Guallar, Víctor; Carrillo, Jorge; Blanco, Julià; Segalés, Joaquim; Clotet, Bonaventura; Vergara-Alert, Júlia; Izquierdo-Useros, Nuria (Frontiers in Pharmacology, 2021-03-25) Sanitat Animal
      There is an urgent need to identify therapeutics for the treatment of Coronavirus disease 2019 (COVID-19). Although different antivirals are given for the clinical management of SARS-CoV-2 infection, ...

    • Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection 

      Ávila-Nieto, Carlos; Vergara-Alert, Júlia; Amengual-Rigo, Pep; Ainsua-Enrich, Erola; Brustolin, Marco; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Rodon, Jordi; Urrea, Victor; Pradenas, Edwards; Marfil, Silvia; Ballana, Ester; Riveira-Muñoz, Eva; Pérez, Mònica; Roca, Núria; Tarrés-Freixas, Ferran; Cantero, Guillermo; Pons-Grífols, Anna; Rovirosa, Carla; Aguilar-Gurrieri, Carmen; Ortiz, Raquel; Barajas, Ana; Trinité, Benjamin; Lepore, Rosalba; Muñoz-Basagoiti, Jordana; Perez-Zsolt, Daniel; Izquierdo-Useros, Nuria; Valencia, Alfonso; Blanco, Julià; Guallar, Victor; Clotet, Bonaventura; Segalés, Joaquim; Carrillo, Jorge (Nature Communications, 2024-03-21) Sanitat Animal
      Safe and effective severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) vaccines are crucial to fight against the coronavirus disease 2019 pandemic. Most vaccines are based on a mutated version ...

    • Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant 

      Ávila-Nieto, Carlos; Vergara-Alert, Júlia; Amengual-Rigo, Pep; Ainsua-Enrich, Erola; Brustolin, Marco; Rodríguez de la Concepción, María Luisa; Pedreño-Lopez, Núria; Rodon, Jordi; Urrea, Victor; Pradenas, Edwards; Marfil, Silvia; Ballana, Ester; Riveira-Muñoz, Eva; Pérez, Mònica; Roca, Núria; Tarrés-Freixas, Ferran; Carabelli, Julieta; Cantero, Guillermo; Pons-Grífols, Anna; Rovirosa, Carla; Aguilar-Gurrieri, Carmen; Ortiz, Raquel; Barajas, Ana; Trinité, Benjamin; Lepore, Rosalba; Muñoz-Basagoiti, Jordana; Perez-Zsolt, Daniel; Izquierdo-Useros, Nuria; Valencia, Alfonso; Blanco, Julià; Clotet, Bonaventura; Guallar, Victor; Segalés, Joaquim; Carrillo, Jorge (Frontiers in Immunology, 2023-12-04) Sanitat Animal
      Most COVID-19 vaccines are based on the SARS-CoV-2 Spike glycoprotein (S) or their subunits. However, S shows some structural instability that limits its immunogenicity and production, hampering the ...

    • Pigs are not susceptible to SARS‐CoV‐2 infection but are a model for viral immunogenicity studies 

      Vergara-Alert, Júlia; Rodon, Jordi; Carrillo, Jorge; Te, Nigeer; Izquierdo-Useros, Nuria; Rodríguez de la Concepción, María Luisa; Ávila-Nieto, Carlos; Guallar, Víctor; Valencia, Alfonso; Cantero, Guillermo; Blanco, Julià; Clotet, Buenaventura; Bensaid, Albert; Segalés, Joaquim (Transboundary and Emerging Diseases, 2020-10-02) Sanitat Animal
      Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. ...

    • Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster 

      Brustolin, Marco; Rodon, Jordi; Rodríguez de la Concepción, María Luisa; Ávila-Nieto, Carlos; Cantero, Guillermo; Pérez, Mónica; Te, Nigeer; Noguera-Julián, Marc; Guallar, Víctor; Valencia, Alfonso; Roca, Núria; Izquierdo-Useros, Nuria; Blanco, Julià; Clotet, Bonaventura; Bensaid, Albert; Carrillo, Jorge; Vergara-Alert, Júlia; Segalés, Joaquim (Emerging Microbes and Infections, 2021-04-29) Sanitat Animal
      Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question ...

    • SARS-CoV-2 infection elicits a rapid neutralizing antibody response that correlates with disease severity 

      Trinité, Benjamin; Tarrés-Freixas, Ferran; Rodon, Jordi; Pradenas, Edwards; Urrea, Víctor; Marfil, Silvia; Rodríguez de la Concepción, María Luisa; Ávila-Nieto, Carlos; Aguilar-Gurrieri, Carmen; Barajas, Ana; Ortiz, Raquel; Paredes, Roger; Mateu, Lourdes; Valencia, Alfonso; Guallar, Víctor; Ruiz, Lidia; Grau, Eulàlia; Massanella, Marta; Puig, Jordi; Chamorro, Anna; Izquierdo-Useros, Nuria; Segalés, Joaquim; Clotet, Bonaventura; Carrillo, Jorge; Vergara-Alert, Júlia; Blanco, Julià (Scientific Reports, 2021-01-28) Sanitat Animal
      The protective effect of neutralizing antibodies in SARS-CoV-2 infected individuals is not yet well defined. To address this issue, we have analyzed the kinetics of neutralizing antibody responses and ...

    • Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes 

      Pradenas, Edwards; Trinité, Benjamin; Urrea, Víctor; Marfil, Silvia; Ávila-Nieto, Carlos; Rodríguez de la Concepción, María Luisa; Tarrés-Freixas, Ferran; Pérez-Yanes, Silvia; Rovirosa, Carla; Ainsua-Enrich, Erola; Rodon, Jordi; Vergara-Alert, Júlia; Segalés, Joaquim; Guallar, Victor; Valencia, Alfonso; Izquierdo-Useros, Nuria; Paredes, Roger; Mateu, Lourdes; Chamorro, Anna; Massanella, Marta; Carrillo, Jorge; Clotet, Bonaventura; Blanco, Julià (Med, 2021-01-31) Sanitat Animal
      Background. Understanding mid-term kinetics of immunity to SARS-CoV-2 is the cornerstone for public health control of the pandemic and vaccine development. However, current evidence is rather based on ...