Now showing items 1-2 of 2
Recombinant PrPSc shares structural features with brain-derived PrPSc: Insights from limited proteolysis
(Plos Pathogens, 2018-01-31)
Very solid evidence suggests that the core of full length PrPSc is a 4-rung β-solenoid, and that individual PrPSc subunits stack to form amyloid fibers. We recently used limited proteolysis to map the ...
Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies
(PLoS Pathogens, 2019-10-23)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long ...