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Understanding the key features of the spontaneous formation of bona fde prions through a novel methodology that enables their swift and consistent generation
(BMC, 2023-09-07)
Among transmissible spongiform encephalopathies or prion diseases afecting humans, sporadic forms such as spo‑
radic Creutzfeldt–Jakob disease are the vast majority. Unlike genetic or acquired forms ...
Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs
(Oxford University Press, 2023-03-22)
Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this ...
Food determines ephemerous and non-stable gut microbiome communities in juvenile wild and farmed Mediterranean fish
(Elsevier, 2023-05-16)
Novel insights were provided by contrasting the composition of wild and farmed fish gut microbiomes because the latter had essentially different environmental conditions from those in the wild. This was ...
Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
(Nature Research, 2023-05-10)
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood. Here we describe ...
A Protein Misfolding Shaking Amplificationbased method for the spontaneous generation of hundreds of bona fide prions
(Nature Research, 2024-03-08)
Prion diseases are a group of rapidly progressing neurodegenerative disorders
caused by the misfolding of the endogenous prion protein (PrPC) into a
pathogenic form (PrPSc). This process, despite being ...
Integrating spatiotemporal hydrological connectivity into conservation planning to protect temporary rivers
(Wiley, 2024-03-25)
1. Temporary rivers (TRs) have been largely overlooked in conservation assessments. Because TRs are such dynamic ecosystems, spatial and temporal aspects of their hydrology and ecology need to be taken ...
Insect glycerol transporters evolved by functional co-option and gene replacement
(Nature Research, 2015-07-17)
Transmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess ...
Bona fide atypical scrapie faithfully reproduced for the first time in a rodent model
(BMC, 2022-12-13)
Atypical Scrapie, which is not linked to epidemics, is assumed to be an idiopathic spontaneous prion disease in small ruminants. Therefore, its occurrence is unlikely to be controlled through selective ...
Living on the Edge: Demography of the Slender-Billed Gull in the Western Mediterranean
(Public Library of Science, 2014-03-24)
Small and peripheral populations are typically vulnerable to local extinction processes but important for the metapopulation dynamics of species. The Slender-billed gull (Chroicocephalus genei) is a ...
Differential kinetics of splenic CD169+ macrophage death is one underlying cause of virus infection fate regulation
(Springer Nature, 2023-12-18)
Acute infection and chronic infection are the two most common fates of pathogenic virus infections. While several factors that
contribute to these fates are described, the critical control points and ...