Skeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves
Ver/Abrir
Autor/a
Yu, Kuai
Matzapetakis, Manolis
Valent, Daniel
Saco, Yolanda
De Almeida, André M.
Terré, Marta
Bassols, Anna
Fecha de publicación
2018-09-14ISSN
2045-2322
Resumen
The efects of diferent amino acid (AA) supplementations of milk protein-based milk replacers
in pre-ruminant calves from 3 days to 7 weeks of age were studied. Animals were divided into 4
groups: Ctrl) Control group fed with milk protein-based milk replacer without supplementation; GP)
supplementation with 0.1% glycine and 0.3% proline; FY) supplementation with 0.2% phenylalanine
and 0.2% tyrosine; MKT) supplementation with 0.62% lysine, 0.22% methionine and 0.61% threonine.
For statistical analysis, t-test was used to compare AA-supplemented animals to the Ctrl group. At week
7, body weight and average daily gain (ADG) were measured and blood samples and skeletal muscle
biopsies were taken. Blood biochemistry analytes related to energy metabolism were determined
and it was shown that MKT group had higher serum creatinine and higher plasma concentration
of three supplemented AAs as well as arginine compared with the Ctrl group. GP group had similar
glycine/proline plasma concentration compared with the other groups while in FY group only plasma
phenylalanine concentration was higher compared with Control. Although the AA supplementations
in the GP and FY groups did not afect average daily gain and metabolic health profle from serum, the
metabolome analysis from skeletal muscle biopsy revealed several diferences between the GP-FY
groups and the Ctrl-MKT groups, suggesting a metabolic adaptation especially in GP and FY groups.
Tipo de documento
Artículo
Versión del documento
Versión publicada
Lengua
Inglés
Materias (CDU)
636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèstics
Páginas
12
Publicado por
Springer Nature
Publicado en
Scientific Reports
Citación
Yu, K., Matzapetakis, M., Valent, D., Saco, Y., De Almeida, A., Terré, M., & Bassols, A. (2018). Skeletal muscle metabolomics and blood biochemistry analysis reveal metabolic changes associated with dietary amino acid supplementation in dairy calves. Scientific Reports, 8(1). doi:10.1038/s41598-018-32241-4
Número del acuerdo de la subvención
MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/AGL2015-68463-C2-1-P/ES/DETERMINACION DE LOS AMINOACIDOS LIMITANTES PARA EL CRECIMIENTO DE LOS TERNEROS AMAMANTADOS Y SU FUNCIONALIDAD/
MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/AGL2015-68463-C2-2-P/ES/ESTUDIO MOLECULAR DE LOS EFECTOS DE LA SUPLEMENTACION DE AMINOACIDOS EN TERNEROS AMAMANTADOS MEDIANTE UNA APROXIMACION BIOQUIMICA Y PROTEOMICA/
Program
Producció de Remugants
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