dc.contributor.author | Lorca-Oro, Cristina | |
dc.contributor.author | Pujols, Joan | |
dc.contributor.author | García-Bocanegra, Ignacio | |
dc.contributor.author | Mentaberre, Gregorio | |
dc.contributor.author | Granados, José Enrique | |
dc.contributor.author | Solanes, David | |
dc.contributor.author | Fandos, Paulino | |
dc.contributor.author | Galindo, Iván | |
dc.contributor.author | Domingo, Mariano | |
dc.contributor.author | Lavín, Santiago | |
dc.contributor.author | López-Olvera, Jorge Ramón | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2024-04-16T13:11:19Z | |
dc.date.available | 2024-04-16T13:11:19Z | |
dc.date.issued | 2012-05-30 | |
dc.identifier.citation | Lorca-Oró, Cristina, Joan Pujols, Ignacio García‐Bocanegra, Gregorio Mentaberre, José Enrique Granados, David Solanes, Paulino Fandós, et al. 2012. “Protection of Spanish Ibex (Capra Pyrenaica) Against Bluetongue Virus Serotypes 1 and 8 in a Subclinical Experimental Infection.” PloS One 7 (5): e36380. doi:10.1371/journal.pone.0036380 | ca |
dc.identifier.issn | 1932-6203 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/2920 | |
dc.description.abstract | Many wild ruminants such as Spanish ibex (Capra pyrenaica) are susceptible to Bluetongue virus (BTV) infection, which
causes disease mainly in domestic sheep and cattle. Outbreaks involving either BTV serotypes 1 (BTV-1) and 8 (BTV-8) are
currently challenging Europe. Inclusion of wildlife vaccination among BTV control measures should be considered in certain
species. In the present study, four out of fifteen seronegative Spanish ibexes were immunized with a single dose of
inactivated vaccine against BTV-1, four against BTV-8 and seven ibexes were non vaccinated controls. Seven ibexes (four
vaccinated and three controls) were inoculated with each BTV serotype. Antibody and IFN-gamma responses were
evaluated until 28 days after inoculation (dpi). The vaccinated ibexes showed significant (P,0.05) neutralizing antibody
levels after vaccination compared to non vaccinated ibexes. The non vaccinated ibexes remained seronegative until
challenge and showed neutralizing antibodies from 7 dpi. BTV RNA was detected in the blood of non vaccinated ibexes
from 2 to the end of the study (28 dpi) and in target tissue samples obtained at necropsy (8 and 28 dpi). BTV-1 was
successfully isolated on cell culture from blood and target tissues of non vaccinated ibexes. Clinical signs were unapparent
and no gross lesions were found at necropsy. Our results show for the first time that Spanish ibex is susceptible and
asymptomatic to BTV infection and also that a single dose of vaccine prevents viraemia against BTV-1 and BTV-8 replication. | ca |
dc.description.sponsorship | This work was supported by the project FAU2008-00019-C03-01, from the Instituto Nacional de Investigacio ´ n y Tecnologı ´a Agroalimentaria (INIA). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | ca |
dc.format.extent | 9 | ca |
dc.language.iso | eng | ca |
dc.publisher | Public Library of Science | ca |
dc.relation.ispartof | PLoS ONE | ca |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Protection of Spanish Ibex (Capra pyrenaica) against Bluetongue Virus Serotypes 1 and 8 in a Subclinical Experimental Infection | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | INIA/Programa Nacional de Proyectos de Investigación Fundamental/FAU2008-00019-C03-01/ES/Epidemiología, control y aspectos entomológicos de la lengua azul (BTV) en rumiantes silvestres en España/ | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0036380 | ca |
dc.contributor.group | Sanitat Animal | ca |