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Comparison of the pathological outcome and disease progression of two Mycobacterium caprae experimental challenge models in goats: endobronchial inoculation vs. intranasal nebulization
(Frontiers Media, 2023-08-11)
Background: Goats are natural hosts of tuberculosis (TB) and are a valid animal model to test new vaccines and treatments to control this disease. In this study, a new experimental model of TB in goats ...
Immunogenicity and protection against Mycobacterium caprae challenge in goats vaccinated with BCG and revaccinated after one year
(MDPI, 2020-12-10)
Vaccination has been proposed as a supplementary tool for the control of tuberculosis in livestock. The long-term immunogenicity elicited by bacillus Calmette-Guerin (BCG) and the efficacy of revaccination ...
A proof‑of‑concept study to investigate the efficacy of heat‑inactivated autovaccines in Mycobacterium caprae experimentally challenged goats
(Nature Research, 2022-12-22)
This study aimed to assess the efficacy of a heat-inactivated Mycobacterium caprae (HIMC) vaccine in goats experimentally challenged with the same strain of M. caprae. Twenty-one goats were divided into ...
Experimental infection of goats with Mycobacterium microti induces subclinical pulmonary tuberculosis and mild responses to tuberculin skin tests
(Elsevier, 2024-01-22)
Mycobacterium microti is a member of the Mycobacterium tuberculosis complex that seldom causes disease in
livestock and humans. This study evaluated the effects on immunodiagnosis and the pathological ...