Identification of an Immunosuppressive Cell Population during Classical Swine Fever Virus Infection and Its Role in Viral Persistence in the Host
Bohorquez, Jose Alejandro
Classical swine fever virus (CSFV) remains a highly important pathogen, causing major losses in the swine industry. Persistent infection is highly relevant for CSFV maintenance in the field; however, this form of infection is not fully understood. An increase in the granulocyte population has been detected in CSFV persistently infected animals. The aim of this work was to evaluate the possible immunosuppressive role of these cells in CSFV persistent infection. The phenotype of peripheral blood and bone marrow cells from persistently infected and naïve animals was evaluated by flow cytometry, and the capacity of specific cell subsets to reduce the interferon gamma (IFN-γ) response against unspecific and specific antigen was determined using co-culture assays. The frequency of granulocytic cells was increased in cells from CSFV persistently infected pigs and they showed a phenotype similar to immunosuppressive cell populations found in persistent infection in humans. These cells from persistently infected animals were able to reduce the IFN-γ response against unspecific and specific antigen. Our results suggest that immature immunosuppressive cell populations play a role in CSFV persistent infection in swine. The information obtained by studying the role of myeloid derived suppressor cells (MDSC) during CSFV persistent infection may extrapolate to other viral persistent infections in mammals.
619 - Veterinària
Is part of
Bohorquez, Muñoz-González, Pérez-Simó, Revilla, Domínguez, and Ganges. 2019. "Identification Of An Immunosuppressive Cell Population During Classical Swine Fever Virus Infection And Its Role In Viral Persistence In The Host". Viruses 11 (9): 822. MDPI AG. doi:10.3390/v11090822.
Grant agreement number
MINECO/Programa estatal de I+D+I orientada a los retos de la sociedad/AGL2015-66907-R/ES/Inmunopatogenia de infecciones persistentes y subclínicas generadas por el virus de la peste porcina clásica/
MINECO/Programa estatal de I+D+I orientada a los retos de la sociedad /RTI2018-100887-B-100/ES/Descifrando nuevos factores virales y del hospedador involucrados en el desarrollo de la peste porcina clásica: implicaciones para el control de la enfermedad/
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