The control of intestinal inflammation: A major objective in the research of probiotic strains as alternatives to antibiotic growth promoters in poultry
The reduction of antimicrobial resistance is a major challenge for the scientific community. In a few decades, infections by resistant bacteria are forecasted to be the main cause of death in the world. The withdrawal of antibiotics as growth promoters and their preventive use in animal production is essential to avoid these resistances, but this may impair productivity and health due to the increase in gut inflammation. This reduction in productivity aggravates the problem of increasing meat demand in developing countries and limits the availability of raw materials. Probiotics are promising products to address this challenge due to their beneficial effects on microbiota composition, mucosal barrier integrity, and immune system to control inflammation. Although many modes of action have been demonstrated, the scientific community is not able to describe the specific effects that a probiotic should induce on the host to maximize both productivity and animal health. First, it may be necessary to define what are the innate immune pathways acting in the gut that optimize productivity and health and to then investigate which probiotic strain is able to induce the specific effect needed. This review describes several gaps in the knowledge of host-microbiota-pathogen interaction and the related mechanisms involved in the inflammatory response not demonstrated yet in poultry.
Updated version (Reprint)
636 - Explotació i cria d'animals. Cria del bestiar i d'animals domèstics
Is part of
Tarradas, Joan, Núria Tous, Enric Esteve-Garcia, and Joaquim Brufau. 2020. "The Control Of Intestinal Inflammation: A Major Objective In The Research Of Probiotic Strains As Alternatives To Antibiotic Growth Promoters In Poultry". Microorganisms 8 (2): 148. MDPI AG. doi:10.3390/microorganisms8020148.
Grant agreement number
MICIU/Programa Estatal de I+D+I orientada a los retos de la Sociedad/RTI2018-098090-A-I00/ES/EVALUACION DE LOS EFECTOS INMUNOMODULADORES INDUCIDOS POR CEPAS PROBIOTICAS (COMO ALTERNATIVA A LOS ANTIBIOTICOS) SOBRE LOS MECANISMOS REGULADORES DE INFLAMACION Y TOLERANCIA/
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