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First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in Spain
(MDPI, 2021-12-16)
Several cases of naturally infected dogs with severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) have been reported despite the apparently low susceptibility of this species. Here, we
document ...
Transmission of severe acute respiratory syndrome coronavirus 2 from humans to animals: is there a risk of novel reservoirs?
(Elsevier, 2023-10-02)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) is a zoonotic virus able to infect humans and multiple
nonhuman animal species. Most natural infections in
companion, captive zoo, ...
Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian Peninsula
(Taylor & Francis Open Access, 2022-02-01)
Middle East respiratory syndrome coronavirus (MERS-CoV) continues infecting humans and dromedary camels. While MERS-CoV strains from the Middle East region are subdivided into two clades (A and B), all ...
Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen
(Frontiers Media, 2021-03-25)
There is an urgent need to identify therapeutics for the treatment of Coronavirus disease 2019 (COVID-19). Although different antivirals are given for the clinical management of SARS-CoV-2 infection, ...
Evaluation of alpaca tracheal explants as an ex vivo model for the study of Middle East respiratory syndrome coronavirus (MERS-CoV) infection
(BMC, 2022-09-02)
Middle East respiratory syndrome coronavirus (MERS-CoV) poses a serious threat to public health. Here, we established an ex vivo alpaca tracheal explant (ATE) model using an air-liquid interface culture ...
Novel Spike-stabilized trimers with improved production protect K18-hACE2 mice and golden Syrian hamsters from the highly pathogenic SARS-CoV-2 Beta variant
(Frontiers Media, 2023-12-04)
Most COVID-19 vaccines are based on the SARS-CoV-2 Spike glycoprotein (S) or
their subunits. However, S shows some structural instability that limits its
immunogenicity and production, hampering the ...
Heterologous Systemic Prime–Intranasal Boosting Using a Spore SARS-CoV-2 Vaccine Confers Mucosal Immunity and Cross-Reactive Antibodies in Mice as well as Protection in Hamsters
(MDPI, 2022-11-10)
Background: Current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are administered systemically and typically result in poor immunogenicity at the mucosa. As a result, vaccination ...
Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster
(Taylor & Francis Open Access, 2021-04-29)
Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question ...
Stable neutralizing antibody levels 6 months after mild and severe COVID-19 episodes
(Elsevier, 2021-01-31)
Background. Understanding mid-term kinetics of immunity to SARS-CoV-2 is the cornerstone for public health control of the pandemic and vaccine development. However, current evidence is rather based on ...