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Mostrando ítems 11-20 de 36
β-Cyclodextrins as affordable antivirals to treat coronavirus infection
(Elsevier, 2023-06-08)
The SARS-CoV-2 pandemic made evident that there are only a few drugs against coronavirus. Here we aimed to identify a cost-effective antiviral with broad spectrum activity and high safety profile. ...
Modelling the spatial risk of malaria through probability distribution of Anopheles maculipennis s.l. and imported cases
(Taylor and Francis, 2024-05-02)
Malaria remains one of the most important infectious diseases globally due to its high incidence and mortality rates. The
influx of infected cases from endemic to non-endemic malaria regions like Europe ...
Navigating through space and time: A methodological approach to quantify spatiotemporal connectivity using stream flow data as a case study
(Wiley, 2023-05-16)
1. The growing interest in combining spatial and temporal patterns in nature has been fostered by the current availability of high-frequency measurements. However, we still lack a methodological framework ...
Aquaporin splice variation differentially modulates channel function during marine teleost egg hydration
(Public Library of Science, 2023-11-27)
Aquaporin-mediated oocyte hydration is a developmentally regulated adaptive mechanism that co-occurs with meiosis resumption in marine teleosts. It provides the early embryos with vital water until ...
Understanding the key features of the spontaneous formation of bona fde prions through a novel methodology that enables their swift and consistent generation
(BMC, 2023-09-07)
Among transmissible spongiform encephalopathies or prion diseases afecting humans, sporadic forms such as spo‑
radic Creutzfeldt–Jakob disease are the vast majority. Unlike genetic or acquired forms ...
Functional Evolution of Clustered Aquaporin Genes Reveals Insights into the Oceanic Success of Teleost Eggs
(Oxford University Press, 2023-03-22)
Aquaporin-mediated oocyte hydration is considered important for the evolution of pelagic eggs and the radiative success of marine teleosts. However, the molecular regulatory mechanisms controlling this ...
Food determines ephemerous and non-stable gut microbiome communities in juvenile wild and farmed Mediterranean fish
(Elsevier, 2023-05-16)
Novel insights were provided by contrasting the composition of wild and farmed fish gut microbiomes because the latter had essentially different environmental conditions from those in the wild. This was ...
Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells
(Nature Research, 2023-05-10)
Latency is a major barrier towards virus elimination in HIV-1-infected individuals. Yet, the mechanisms that contribute to the maintenance of HIV-1 latency are incompletely understood. Here we describe ...
A Protein Misfolding Shaking Amplificationbased method for the spontaneous generation of hundreds of bona fide prions
(Nature Research, 2024-03-08)
Prion diseases are a group of rapidly progressing neurodegenerative disorders
caused by the misfolding of the endogenous prion protein (PrPC) into a
pathogenic form (PrPSc). This process, despite being ...
Reproductive behaviour and fertilized spawns in cultured Solea senegalensis broodstock co-housed with wild breeders during their juvenile stages
(Elsevier, 2024-05-07)
The reproductive failure of Senegalese sole (Solea senegalensis) cultured males (reared entirely in captivity from egg through to adult) that do not participate in reproductive behaviours to fertilise ...