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Classical BSE prions emerge from asymptomatic pigs challenged with atypical/Nor98 scrapie
(Nature Research, 2021-08-31)
Pigs are susceptible to infection with the classical bovine spongiform encephalopathy (C-BSE) agent following experimental inoculation, and PrPSc accumulation was detected in porcine tissues after the ...
Porcine Forebrain Vacuolization Associated with Wasting in Pigs: A Novel Pathological Outcome Associated with Vitamin–Mineral Deficiency?
(MDPI, 2023-07-10)
The term wasting refers to a clinical sign used to describe a physical condition characterized
by growth retardation, usually of multifactorial origin. The objective of the present study was to
describe ...
Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates
(Public Library of Science, 2015-08-06)
Interspecies transmission of prions is a well-established phenomenon, both experimentally and under field conditions. Upon passage through new hosts, prion strains have proven their capacity to change ...
Systems analysis reveals complex biological processes during virus infection fate decisions
(Cold Spring Harbor Laboratory Press, 2019-05-28)
The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an ...
Experimental Mycobacterium microti Infection in Bank Voles (Myodes glareolus)
(MDPI, 2022-01-10)
Voles are maintenance hosts of Mycobacterium microti. In line with the goal to eradicate tuberculosis (TB) in livestock, the role of this mycobacteria needs to be assessed since it might interfere with ...
First Report of Streptococcus ruminantium in Wildlife: Phenotypic Differences with a Spanish Domestic Ruminant Isolate
(MDPI, 2022-02-08)
Streptococcus ruminantium is a recent reclassification of the former Streptococcus suis serovar 33. Although knowledge about S. suis is extensive, information on S. ruminantium host range and pathogenic ...
Generalized tuberculosis due to Mycobacterium caprae in a red fox phylogenetically related to livestock breakdowns
(BMC, 2022-09-20)
Background
Tuberculosis (TB) due to Mycobacterium caprae is endemic in goat herds and free-ranging wild boars in Spain, causing infections in other livestock or wild animals to a lesser extent. TB ...
Understanding the key features of the spontaneous formation of bona fde prions through a novel methodology that enables their swift and consistent generation
(BMC, 2023-09-07)
Among transmissible spongiform encephalopathies or prion diseases afecting humans, sporadic forms such as spo‑
radic Creutzfeldt–Jakob disease are the vast majority. Unlike genetic or acquired forms ...
Phylogenetic relationships investigation of Mycobacterium caprae strains from sympatric wild boar and goats based on whole genome sequencing
(Wiley, 2020-09-05)
Tuberculosis (TB) in wildlife challenges epidemiological surveillance and disease control. An outbreak of TB was detected in a free‐ranging wild boar population of a Natural Park in Catalonia (Spain) ...
The emergence of classical BSE from atypical/Nor98 scrapie
(National Academy of Sciences, 2019-12-16)
Atypical/Nor98 scrapie (AS) is a prion disease of small ruminants. Currently there are no efficient measures to control this form of prion disease, and, importantly, the zoonotic potential and the risk ...