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Heterologous Systemic Prime–Intranasal Boosting Using a Spore SARS-CoV-2 Vaccine Confers Mucosal Immunity and Cross-Reactive Antibodies in Mice as well as Protection in Hamsters
(MDPI, 2022-11-10)
Background: Current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are administered systemically and typically result in poor immunogenicity at the mucosa. As a result, vaccination ...
Multisystemic lymphoplasmacytic inflammation associated with PCV-3 in wasting pigs
(Wiley, 2021-07-30)
Porcine circovirus 3 (PCV-3) has been detected in diseased and healthy pigs of different ages. Several reports have associated the agent with reproductive failure and mummified and stillborn piglets. ...
Porcine circovirus 2 (PCV-2) genetic variability under natural infection scenario reveals a complex network of viral quasispecies
(Nature Research, 2018-10-19)
Porcine circovirus 2 (PCV-2) is a virus characterized by a high evolutionary rate, promoting the potential
emergence of diferent genotypes and strains. Despite the likely relevance in the emergence of ...
Detection of SARS-CoV-2 in a cat owned by a COVID-19−affected patient in Spain
(National Academy of Sciences, 2020-09-18)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is considered a zoonotic pathogen mainly transmitted human to human. Few reports indicate that pets may ...
Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice
(Frontiers Media, 2022-05-04)
The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced transmissibility, more severity and/or immune evasion; however, the pathogenesis of these new VOCs in experimental SARS-CoV-2 ...
Clinical course impacts early kinetics,magnitude, and amplitude of SARS-CoV-2 neutralizing antibodies beyond 1 year after infection
(Cell Press, 2022-01-24)
To understand the determinants of long-term immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the concurrent impact of vaccination and emerging variants, we follow a ...
Clinical, Pathological and Virological Outcomes of Tissue-Homogenate-Derived and Cell-Adapted Strains of Porcine Epidemic Diarrhea Virus (PEDV) in a Neonatal Pig Model
(MDPI, 2023-12-27)
Porcine epidemic diarrhea virus (PEDV) is characterized by diarrhea, vomiting, dehydration, and high mortality rates in neonatal piglets. Two distinct genogroups, S-INDEL (G1a, G1b) and
non-S INDEL ...
Acclimation strategies in gilts to control Mycoplasma hyopneumoniae infection
(Elsevier, 2018-04-04)
This paper discusses what can be expected with regard to efficacy of antibacterial vaccines used in swine, based on the present knowledge of pathogen–host interactions. First, vaccination against bacteria ...
Histopathological and virological findings in emaciated pigs from Mexico: an exploratory study
(University of Veterinary and Pharmaceutical Sciences, Brno, 2018-06-27)
The objective of this work was to detect the presence of three main pig respiratory viral agents
(porcine rubulavirus [PorPV], porcine circovirus type 2 [PCV-2], and porcine reproductive and
respiratory ...