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Experimental and field investigations of exposure, replication and transmission of SARS-CoV-2 in pigs in the Netherlands
(Taylor & Francis Open Access, 2021-12-21)
In order to assess the risk of SARS-CoV-2 infection, transmission and reservoir development in swine, we combined results of an experimental and two observational studies. First, intranasal and intratracheal ...
Preclinical and randomized phase I studies of plitidepsin in adults hospitalized with COVID-19
(Life Science Alliance, 2022-01-10)
Plitidepsin, a marine-derived cyclic-peptide, inhibits SARS-CoV-2 replication at nanomolar concentrations by targeting the host protein eukaryotic translation elongation factor 1A. Here, we show that ...
Identification of Plitidepsin as Potent Inhibitor of SARS-CoV-2-Induced Cytopathic Effect After a Drug Repurposing Screen
(Frontiers Media, 2021-03-25)
There is an urgent need to identify therapeutics for the treatment of Coronavirus disease 2019 (COVID-19). Although different antivirals are given for the clinical management of SARS-CoV-2 infection, ...
Detection of SARS-CoV-2 in a cat owned by a COVID-19−affected patient in Spain
(National Academy of Sciences, 2020-09-18)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, is considered a zoonotic pathogen mainly transmitted human to human. Few reports indicate that pets may ...
Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein
(Taylor & Francis Open, 2019-11-12)
The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission from dromedary camels, the animal reservoir, ...
Chronological brain lesions after SARS-CoV-2 infection in hACE2-transgenic mice
(SAGE Publications, 2021-12-27)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes respiratory disease, but it can also affect other organs including the central nervous system. Several animal models have been developed ...
First Detection of SARS-CoV-2 Delta (B.1.617.2) Variant of Concern in a Dog with Clinical Signs in Spain
(MDPI, 2021-12-16)
Several cases of naturally infected dogs with severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2) have been reported despite the apparently low susceptibility of this species. Here, we
document ...
Enhanced replication fitness of MERS-CoV clade B over clade A strains in camelids explains the dominance of clade B strains in the Arabian Peninsula
(Taylor & Francis Open Access, 2022-02-01)
Middle East respiratory syndrome coronavirus (MERS-CoV) continues infecting humans and dromedary camels. While MERS-CoV strains from the Middle East region are subdivided into two clades (A and B), all ...
Pigs are not susceptible to SARS‐CoV‐2 infection but are a model for viral immunogenicity studies
(Wiley, 2020-10-02)
Conventional piglets were inoculated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through different routes, including intranasal, intratracheal, intramuscular and intravenous ones. ...
Type I and III IFNs produced by the nasal epithelia and dimmed inflammation are features of alpacas resolving MERS-CoV infection
(Public Library of Science, 2021-05-24)
While MERS-CoV (Middle East respiratory syndrome Coronavirus) provokes a lethal disease in humans, camelids, the main virus reservoir, are asymptomatic carriers, suggesting a crucial role for innate ...