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Systems analysis reveals complex biological processes during virus infection fate decisions
(Cold Spring Harbor Laboratory Press, 2019-05-28)
The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an ...
The emergence of classical BSE from atypical/Nor98 scrapie
(National Academy of Sciences, 2019-12-16)
Atypical/Nor98 scrapie (AS) is a prion disease of small ruminants. Currently there are no efficient measures to control this form of prion disease, and, importantly, the zoonotic potential and the risk ...
Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies
(Public Library of Science, 2019-10-23)
The resolution of the three-dimensional structure of infectious prions at the atomic level is pivotal to understand the pathobiology of Transmissible Spongiform Encephalopathies (TSE), but has been long ...
Mycobacterium microti Infection in free-ranging wild boar, Spain, 2017-2019
(Centers for Disease Control and Prevention, 2019-11-25)
Mycobacterium microti is a member of the Mycobacterium tuberculosis complex that causes pathology in many mammals. M. microti infections have been found in some countries in Europe. We report an outbreak ...
CSF neurogranin as a neuronal damage marker in CJD: a comparative study with AD
(BMJ Publishing Group, 2019-05-16)
Objective To investigate whether cerebrospinal fluid (CSF) neurogranin concentrations are altered in sporadic Creutzfeldt-Jakob disease (CJD), comparatively with Alzheimer’s disease (AD), and associated ...
Cutaneous apocrine cystomatosis in three slaughter-aged pigs
(SAGE Publications, 2019-12-09)
Apocrine cystomatosis is a rare condition characterized by clusters of cystically dilated sweat glands or other specialized apocrine glands. Cystic dilation of cutaneous sweat glands has been described ...
DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs
(Public Library of Science, 2019-09-25)
Swine influenza virus (SIVs) infections cause a significant economic impact to the pork industry.
Moreover, pigs may act as mixing vessel favoring genome reassortment of diverse influenza
viruses. ...
Conserved HA-peptide NG34 formulated in pCMV-CTLA4-Ig reduces viral shedding in pigs after a heterosubtypic influenza virus SwH3N2 challenge
(Public Library of Science, 2019-03-01)
Swine influenza viruses (SIVs), the causal agents of swine influenza, are not only important to control due to the economic losses in the swine industry, but also can be pandemic pathogens. Vaccination ...