Browsing by Author "Arís, Anna"
Now showing items 1-20 of 31
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A new generation of recombinant polypeptides combines multiple protein domains for effective antimicrobial activity
Roca-Pinilla, Ramon; López-Cano, Adrià; Saubi, Cristina; Garcia-Fruitos, Elena; Arís, Anna (Microbial Cell Factories, 2020-06-05) Producció de RemugantsBackground Although most of antimicrobial peptides (AMPs), being relatively short, are produced by chemical synthesis, several AMPs have been produced using recombinant technology. However, AMPs could ... -
A Novel Generation of Tailored Antimicrobial Drugs Based on Recombinant Multidomain Proteins
López-Cano, Adrià; Ferrer-Miralles, Neus; Sánchez, Julieta; Carratalá, Jose Vicente; Rodriguez Rodriguez, Xavier; Ratera, Imma; Guasch, Judith; Pich, Oscar Q.; Bierge, Paula; Garcia-de-la-Maria, Cristina; Miro, Jose M.; Garcia-Fruitos, Elena; Arís, Anna (Pharmaceutics, 2023-03-26) Producció de RemugantsAntibiotic resistance has exponentially increased during the last years. It is necessary to develop new antimicrobial drugs to prevent and treat infectious diseases caused by multidrug- or extensively-drug ... -
Aggregation-prone peptides modulate activity of bovine interferon gamma released from naturally occurring protein nanoparticles
Carratalá, José Vicente; Cano‐Garrido, Olivia; Sánchez, Julieta; Membrado, Cristina; Pérez, Eudald; Conchillo‐Solé, Oscar; Daura, Xavier; Sánchez‐Chard, Alejandro; Villaverde, Antonio; Arís, Anna; Garcia‐Fruitós, Elena; Ferrer‐Miralles, Neus (New Biotechnology, 2020-02-03) Producció de RemugantsEfficient protocols for the production of recombinant proteins are indispensable for the development of the biopharmaceutical sector. Accumulation of recombinant proteins in naturally-occurring protein ... -
Antibiofilm surfaces based on the immobilization of a novel recombinant antimicrobial multidomain protein using self-assembled monolayers
Kyvik, Adriana R.; Roca, Ramon; Mayolo-Deloisa, Karla; Rodriguez Rodriguez, Xavier; Martinez-Miguel, Marc; Martos, Marta; Köber, Mariana; Ventosa, Nora; Veciana, Jaume; Guasch, Judith; Garcia-Fruitos, Elena; Arís, Anna; Ratera, Imma (Materials Advances, 2023-04-13) Producció de RemugantsThe constant increase of microorganisms resistant to antibiotics has been classified as a global health emergency, which is especially challenging when biofilms are formed. Herein, novel biofunctionalized ... -
CCL21-loaded 3D hydrogels for T cell expansion and differentiation
Pérez del Río, Eduardo; Santos, Fabião; Rodriguez Rodriguez, Xavier; Martínez-Miguel, Marc; Roca-Pinilla, Ramon; Arís, Anna; Garcia-Fruitos, Elena; Veciana, Jaume; Spatz, Joachim P.; Ratera, Imma; Guasch, Judith (Biomaterials, 2020-08-13) Producció de RemugantsRecent achievements in the field of immunotherapy, such as the development of engineered T cells used in adoptive cell therapy, are introducing more efficient strategies to combat cancer. Nevertheless, ... -
Citrus aurantium flavonoid extract improves concentrate efficiency, animal behavior, and reduces rumen inflammation of Holstein bulls fed high-concentrate diets
Paniagua, Montserrat; Crespo, Javier; Arís, Anna; Devant, Maria (Animal Feed Science and Technology, 2019-10-10) Producció de RemugantsOne hundred fourty-four bulls (164.8 ± 5.91 kg BW and 135 ± 7.2 d of age) were randomly allocated to one of 8 pens and assigned to control (C) or citrus flavonoid (BF) treatments (Citrus aurantium, ... -
Citrus Flavonoids Supplementation as an Alternative to Replace Zinc Oxide in Weanling Pigs’ Diets Minimizing the Use of Antibiotics
Paniagua, Montserrat; Villagómez-Estrada, Sandra; Crespo, Francisco Javier; Pérez, José Francisco; Arís, Anna; Devant, Maria; Solà-Oriol, David (Animals, 2023-03-07) Producció de RemugantsSince citrus flavonoids have antioxidant and anti-inflammatory properties, it was hypothesized that these compounds would become a suitable alternative to the use of therapeutic doses of zinc oxide at ... -
Design strategies for positively charged endolysins: Insights into Artilysin development
Carratalá, Jose Vicente; Arís, Anna; Garcia-Fruitos, Elena; Ferrer-Miralles, Neus (Biotechnology Advances, 2023-09-06) Producció de RemugantsEndolysins are bacteriophage-encoded enzymes that can specifically degrade the peptidoglycan layer of bacterial cell wall, making them an attractive tool for the development of novel antibacterial agents. ... -
Effect of metritis on endometrium tissue transcriptome during puerperium in Holstein lactating cows
Genís, Sandra; Arís, Anna; Kaur, Manveen; Cerri, Ronaldo L.A. (Theriogenology, 2018-09-15) Producció de RemugantsThe objective of this prospective cohort study was to evaluate the effect of parity and uterine healthstatus postpartum on the gene expression profile of the endometrium early post-partum. Twenty-fourHolstein ... -
Effects of Flavonoids Extracted from Citrus aurantium on Performance, Behavior, and Rumen Gene Expression in Holstein Bulls Fed with High-Concentrate Diets in Pellet Form
Paniagua, Montserrat; Crespo, Francisco Javier; Arís, Anna; Devant, Maria (Animals, 2021-05-13) Producció de RemugantsFlavonoid supplementation may modify the behavior and rumen inflammatory response of fattening bulls, and this could be related to the concentrate presentation (mash or pellet) form. In the present ... -
Exploring the impact of the recombinant Escherichia coli strain on defensins antimicrobial activity: BL21 versus Origami strain
López-Cano, Adrià; Martínez-Miguel, Marc; Guasch, Judith; Ratera, Imma; Arís, Anna; Garcia-Fruitos, Elena (Microbial Cell Factories, 2022-05-09) Producció de RemugantsThe growing emergence of microorganisms resistant to antibiotics has prompted the development of alternative antimicrobial therapies. Among them, the antimicrobial peptides produced by innate immunity, ... -
Exploring the use of leucine zippers for the generation of a new class of inclusion bodies for pharma and biotechnological applications
Roca-Pinilla, Ramon; Fortuna, Sara; Natalello, Antonino; Sánchez-Chardi, Alejandro; Ami, Diletta; Arís, Anna; Garcia-Fruitos, Elena (Microbial Cell Factories, 2020-09-04) Producció de RemugantsBackground Inclusion bodies (IBs) are biologically active protein aggregates forming natural nanoparticles with a high stability and a slow-release behavior. Because of their nature, IBs have been ... -
Getting value from the waste: recombinant production of a sweet protein by Lactococcus lactis grown on cheese whey
Boumaiza, Mohamed; Colarusso, Andrea; Parrilli, Ermenegilda; Garcia-Fruitos, Elena; Casillo, Angela; Arís, Anna; Corsaro, Maria Michela; Picone, Delia; Leone, Serena; Tutino, Maria Luisa (Microbial Cell Factories, 2018-08-15) Producció de RemugantsBackground Recent biotechnological advancements have allowed for the adoption of Lactococcus lactis, a typical component of starter cultures used in food industry, as the host for the production of ... -
Immunomodulation Evidence of Nanostructured Recombinant Proteins in Salmonid Cells
Torrealba, Débora; López, Daniela; Zelada, Patricio; Salinas-Parra, Nicolás; Valenzuela-Avilés, Paula; Garcia-Fruitós, Elena; Arís, Anna; Mercado, Luis; Altamirano, Claudia; Gallardo-Matus, José (Animals, 2024-03-09) Producció de RemugantsRecent studies have demonstrated that immune-related recombinant proteins can enhance immune function, increasing host survival against infectious diseases in salmonids. This research evaluated inclusion ... -
In Vivo Bactericidal Efficacy of GWH1 Antimicrobial Peptide Displayed on Protein Nanoparticles, a Potential Alternative to Antibiotics
Carratalá, Jose V.; Brouillette, Eric; Serna, Naroa; Sánchez-Chardi, Alejandro; Sánchez, Julieta M.; Villaverde, Antonio; Arís, Anna; Garcia-Fruitos, Elena; Ferrer-Miralles, Neus; Malouin, François (Pharmaceutics, 2020-12-17) Producció de RemugantsOligomerization of antimicrobial peptides into nanosized supramolecular complexes produced in biological systems (inclusion bodies and self-assembling nanoparticles) seems an appealing alternative to ... -
Lactiplantibacillus plantarum: a new example of inclusion body producing bacteria
Baltà, Ricardo; Serrano-Adrover, Caterina; López-Cano, Adrià; Gifre-Renom, Laia; Sanchez-Chardi, Alejandro; Arís, Anna; Garcia-Fruitos, Elena (Microbial Cell Factories, 2023-06-09) Producció de RemugantsBackground Lactic Acid Bacteria such as Lactococcus lactis, Latilactobacillus sakei (basonym: Lactobacillus sakei) and Lactiplantibacillus plantarum (basonym: Lactobacillus plantarum) have gained ... -
Leche de descarte y residuos de antibióticos
Arís, Anna; Terré, Marta; García-Fruitós, Elena (Albéitar, 2023, 262, Sept/Oct, 20-22, 2023-09) Producció de RemugantsEl uso de antibióticos para el tratamiento de infecciones en las vacas lecheras durante la lactación genera la leche de descarte. Esta es una leche que contiene residuos de antibióticos y que no se ... -
Potential of MMP-9 based nanoparticles at optimizing the cow dry period: pulling apart the effects of MMP-9 and nanoparticles
Gifre-Renom, L.; Carratalá, J. V.; Parés, S.; Sánchez-García, L.; Ferrer-Miralles, N.; Villaverde, A.; Bach, A.; Garcia-Fruitos, Elena; Arís, Anna (Scientific Reports, 2020-07-09) Producció de RemugantsThe cow dry period is a non-milking interval where the mammary gland involutes and regenerates to guarantee an optimal milk production in the subsequent lactation. Important bottlenecks such as the ... -
Potential of Oral Nanoparticles Containing Cytokines as Intestinal Mucosal Immunostimulants in Pigs: A Pilot Study
López-Cano, Adrià; Bach, Alex; López-Serrano, Sergi; Aragon, Virginia; Blanch, Marta; Pastor, Jose J.; Tedó, Gemma; Morais, Sofia; Garcia-Fruitos, Elena; Arís, Anna (Animals, 2022-04-21) Sanitat Animal; Producció de Remugants; Producció de RemugantsAntimicrobial resistance is a global threat that is worryingly rising in the livestock sector. Among the proposed strategies, immunostimulant development appears an interesting approach to increase ... -
Pre-calving intravaginal administration of lactic acid bacteria reduces metritis prevalence and regulates blood neutrophil gene expression after calving in dairy cattle
Genís, Sandra; Cerri, Ronaldo L. A.; Bach, Àlex; Silper, Bruna F.; Baylão, Matheus; Denis-Robichaud, José; Arís, Anna (Frontiers in Veterinary Science, 2018-06-21) Producció de RemugantsMetritis affects up to 40% of dairy cows and it is usually treated with antibiotics. In spite of their advantages, there is an increased concern about antibiotic resistance leading to the research of ...