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dc.contributor.authorSerra-Compte, Albert
dc.contributor.authorPikkemaat, Mariël G.
dc.contributor.authorElferink, Alexander
dc.contributor.authorAlmeida, David
dc.contributor.authorDiogène, Jorge
dc.contributor.authorCampillo, Juan Antonio
dc.contributor.authorLlorca, Marta
dc.contributor.authorÁlvarez-Muñoz, Diana
dc.contributor.authorBarceló, Damià
dc.contributor.authorRodríguez-Mozaz, Sara
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-01-18T12:43:28Z
dc.date.issued2020-12-15
dc.identifier.citationSerra-Compte, Albert, Mariël G. Pikkemaat, Alexander Elferink, David Almeida, Jorge Diogène, Juan Antonio Campillo, Marta Llorca, Diana Álvarez-Muñoz, Damià Barceló, and Sara Rodríguez-Mozaz. 2021. "Combining An Effect-Based Methodology With Chemical Analysis For Antibiotics Determination In Wastewater And Receiving Freshwater And Marine Environment". Environmental Pollution 271: 116313. doi:10.1016/j.envpol.2020.116313.ca
dc.identifier.issn0269-7491ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1047
dc.description.abstractTwo different methodologies were combined to evaluate the risks that antibiotics can pose in the environment; i) an effect-based methodology based on microbial growth inhibition and ii) an analytical method based on liquid-chromatography coupled to mass spectrometry (LC-MS). The first approach was adapted and validated for the screening of four antibiotic families, specifically macrolides/β-lactams, quinolones, sulfonamides and tetracyclines. The LC-MS method was applied for the identification and quantification of target antibiotics; then, the obtained results were combined with ecotoxicological data from literature to determine the environmental risk. The two methodologies were used for the analysis of antibiotics in water samples (wastewater, river water and seawater) and biofluids (fish plasma and mollusk hemolymph) in two monitoring campaigns undertaken in the Ebro Delta and Mar Menor Lagoon (both in the Mediterranean coast of Spain). Both approaches highlighted macrolides (azithromycin) and quinolones (ciprofloxacin and ofloxacin) as the main antibiotics in wastewater treatment plant (WWTP) effluents with potential risk for the environment. However, no risk for the aquatic life was identified in the river, lagoon and seawater as antibiotic levels were much lower than those in WWTP effluents. Fish from Ebro River were the organisms presenting the highest antibiotic concentration when compared with bivalves (mussels) from the Mediterranean Sea and gastropods (marine snails) from the Mar Menor Lagoon. The effect-based methodology successfully determined antibiotic risk in wastewater, but its applicability was less clear in environmental waters such as seawater, due to its high detection limits. Improving sample preconcentration could increase the method sensibility. Overall, combination of both methodologies provides comprehensive insights in antibiotic occurrence and risk associated in areas under study.ca
dc.format.extent36ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofEnvironmental Pollutionca
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleCombining an effect-based methodology with chemical analysis for antibiotics determination in wastewater and receiving freshwater and marine environmentca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/embargoedAccess
dc.date.embargoEnd2022-12-15T01:00:00Z
dc.embargo.terms24 mesosca
dc.relation.projectIDMINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/CTM2017-89701-C3-2-R/MICROPLASTICOS Y MICROCONTAMINANTES EN LA COSTA MEDITERRANEA. TOXICIDAD E IMPACTO AMBIENTAL Y EN LA SALUD HUMANA/PLASMEDca
dc.relation.projectIDMINECO-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/CTM2015-73179-JIN/ES/Identificación de xenobioticos bioacumulables en mejillón siguiendo un enfoque metabolomico: exposición humana y ambiental/XENOMETABOLOMICca
dc.relation.projectIDMINECO/ /RYC2014-16707/ES/ /ca
dc.subject.udc574ca
dc.identifier.doihttps://doi.org/10.1016/j.envpol.2020.116313ca
dc.contributor.groupAigües Marines i Continentalsca


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