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dc.contributor.authorPérez del Río, Eduardo
dc.contributor.authorSantos, Fabião
dc.contributor.authorRodriguez Rodriguez, Xavier
dc.contributor.authorMartínez-Miguel, Marc
dc.contributor.authorRoca-Pinilla, Ramon
dc.contributor.authorArís, Anna
dc.contributor.authorGarcia-Fruitós, Elena
dc.contributor.authorVeciana, Jaume
dc.contributor.authorSpatz, Joachim P.
dc.contributor.authorRatera, Imma
dc.contributor.authorGuasch, Judith
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-02-03T14:28:53Z
dc.date.available2021-02-03T14:28:53Z
dc.date.issued2020-08-13
dc.identifier.citationPérez del Río, Eduardo, Fabião Santos, Xavier Rodriguez Rodriguez, Marc Martínez-Miguel, Ramon Roca-Pinilla, Anna Arís, and Elena Garcia-Fruitós et al. 2020. "CCL21-Loaded 3D Hydrogels For T Cell Expansion And Differentiation". Biomaterials 259: 120313. doi:10.1016/j.biomaterials.2020.120313.ca
dc.identifier.issn0142-9612ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1066
dc.description.abstractRecent achievements in the field of immunotherapy, such as the development of engineered T cells used in adoptive cell therapy, are introducing more efficient strategies to combat cancer. Nevertheless, there are still many limitations. For example, these T cells are challenging to manufacture, manipulate, and control. Specifically, there are limitations in producing the large amounts of therapeutic T cells needed for these therapies in a short period of time and in an economically viable manner. In this study, three-dimensional (3D) poly(ethylene) glycol (PEG) hydrogels covalently combined with low molecular weight heparin are engineered to resemble the lymph nodes, where T cells reproduce. In these hydrogels, PEG provides the needed structural and mechanical properties, whereas heparin is used as an anchor for the cytokine CCL21, which is present in the lymph nodes, and can affect cell migration and proliferation. The 3D structure of the hydrogel in combination with its loading capacity result in an increased primary human CD4+ T cell proliferation compared to the state-of-the-art expansion systems consisting of artificial antigen presenting cells. Thus, we present a new tool for adoptive cell therapy to help achieving the large numbers of cells required for therapy of selected phenotypes targeted against cancer cells, by mimicking the lymph nodes.ca
dc.format.extent13ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofBiomaterialsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleCCL21-loaded 3D hydrogels for T cell expansion and differentiationca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/MAT2016-80826-R/ES/MATERIALES MOLECULARES Y ORGANIZACIONES SUPRAMOLECULARES PARA TERAPIA, DIAGNOSIS E INGENIERIA TISULAR/ca
dc.relation.projectIDMICIU/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/PID2019-105622RB-I00/ES/PROCESAMIENTO DE MOLECULAS PARA CREAR MATERIALES HIBRIDOS ESTRUCTURADOS JERARQUICAMENTE PARA APLICACIONES BIOMEDICAS/ca
dc.relation.projectIDMINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC-2017-22614/ES/ /ca
dc.relation.projectIDEC/H2020/600388/EU/ACCIÓ programme to foster mobility of researchers with a focus in applied research and technology transfer/TECNIOspring PLUSca
dc.relation.projectIDEC/H2020/754397/EU/DOCtoral training programme in Functional Advanced Materials/DOC-FAMca
dc.relation.projectIDMINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/SEV-2015-0496/ES/ /ca
dc.subject.udc577ca
dc.identifier.doihttps://doi.org/10.1016/j.biomaterials.2020.120313ca
dc.contributor.groupProducció de Remugantsca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/