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dc.contributor.authorArrieta-Villegas, Claudia
dc.contributor.authorAllepuz, Alberto
dc.contributor.authorGrasa, Miriam
dc.contributor.authorMartín, Maite
dc.contributor.authorCervera, Zoraida
dc.contributor.authorMercader, Irene
dc.contributor.authorLópez-Soria, Sergio
dc.contributor.authorDomingo, Mariano
dc.contributor.authorPérez de Val, Bernat
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-02-23T10:56:10Z
dc.date.available2021-02-23T10:56:10Z
dc.date.issued2020-11-23
dc.identifier.citationArrieta-Villegas, Claudia, Alberto Allepuz, Miriam Grasa, Maite Martín, Zoraida Cervera, Irene Mercader, Sergio López-Soria, Mariano Domingo, and Bernat Pérez de Val. 2020. "Long-Term Efficacy Of BCG Vaccination In Goat Herds With A High Prevalence Of Tuberculosis". Scientific Reports 10 (1). doi:10.1038/s41598-020-77334-1.ca
dc.identifier.issn2045-2322ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1133
dc.description.abstractVaccination of goats against tuberculosis (TB) has been promoted as an ancillary tool for controlling the disease in infected livestock herds. A three-year trial to assess the efficacy of BCG vaccine was carried out in five goat herds. At the beginning of the trial (month 0), all animals were tested for TB using thee different diagnostic tests. Animals negative to all tests were vaccinated with BCG and all replacement goat kids were also systematically vaccinated throughout the trial. All animals were tested by Interferon-gamma release assay (IGRA) using vaccine compatible reagents at months 6, 12, 24, and 36. The risk factors for TB infection were also evaluated. At the end of the study, four out of five farms showed variable reductions of the initial prevalence (93.5%, 28.5%, 23.2%, and 14.3% respectively), and an overall incidence reduction of 50% was observed in BCG vaccinated goats, although adult vaccinated goats showed higher incidences than vaccinated goat kids. The unvaccinated positive animals remaining in herds and adult BCG vaccinated goats significantly enhanced the risk of infection in vaccinated animals. A systematic vaccination of goats with BCG, together with the removal of positive unvaccinated animals, may contribute to reducing the TB prevalence in goat herds.ca
dc.format.extent12ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofScientific Reportsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleLong-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosisca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDINIA-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTA2015-00043-C02-00/ES/Diagnóstico, vacunación y nuevas herramientas de lucha frente a la tuberculosis en la especie caprina/DVNHLFca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.1038/s41598-020-77334-1ca
dc.contributor.groupSanitat Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/