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dc.contributor.authorLund, Peter A.
dc.contributor.authorDe Biase, Daniela
dc.contributor.authorLiran, Oded
dc.contributor.authorScheler, Ott
dc.contributor.authorPereira Mira, Nuno
dc.contributor.authorCetecioglu, Zeynep
dc.contributor.authorNoriega Fernández, Estefanía
dc.contributor.authorBover-Cid, Sara
dc.contributor.authorHall, Rebecca
dc.contributor.authorSauer, Michael
dc.contributor.authorO’Byrne, Conor
dc.contributor.otherIndústries Alimentàriesca
dc.date.accessioned2021-02-24T14:19:40Z
dc.date.available2021-02-24T14:19:40Z
dc.date.issued2020-09-24
dc.identifier.citationLund, Peter A., Daniela De Biase, Oded Liran, Ott Scheler, Nuno Pereira Mira, Zeynep Cetecioglu, and Estefanía Noriega Fernández et al. 2020. "Understanding How Microorganisms Respond To Acid Ph Is Central To Their Control And Successful Exploitation". Frontiers In Microbiology 11. doi:10.3389/fmicb.2020.556140.ca
dc.identifier.issn1664-302Xca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1147
dc.description.abstractMicrobes from the three domains of life, Bacteria, Archaea, and Eukarya, share the need to sense and respond to changes in the external and internal concentrations of protons. When the proton concentration is high, acidic conditions prevail and cells must respond appropriately to ensure that macromolecules and metabolic processes are sufficiently protected to sustain life. While, we have learned much in recent decades about the mechanisms that microbes use to cope with acid, including the unique challenges presented by organic acids, there is still much to be gained from developing a deeper understanding of the effects and responses to acid in microbes. In this perspective article, we survey the key molecular mechanisms known to be important for microbial survival during acid stress and discuss how this knowledge might be relevant to microbe-based applications and processes that are consequential for humans. We discuss the research approaches that have been taken to investigate the problem and highlight promising new avenues. We discuss the influence of acid on pathogens during the course of infections and highlight the potential of using organic acids in treatments for some types of infection. We explore the influence of acid stress on photosynthetic microbes, and on biotechnological and industrial processes, including those needed to produce organic acids. We highlight the importance of understanding acid stress in controlling spoilage and pathogenic microbes in the food chain. Finally, we invite colleagues with an interest in microbial responses to low pH to participate in the EU-funded COST Action network called EuroMicropH and contribute to a comprehensive database of literature on this topic that we are making publicly available.ca
dc.format.extent8ca
dc.language.isoengca
dc.publisherFrontiers Mediaca
dc.relation.ispartofFrontiers in Microbiologyca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleUnderstanding How Microorganisms Respond to Acid pH Is Central to Their Control and Successful Exploitationca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDEC/COST/CA18113/EU/Understanding and exploiting the impacts of low pH on micro-organisms/EuroMicropHca
dc.subject.udc663/664ca
dc.identifier.doihttps://doi.org/10.3389/fmicb.2020.556140ca
dc.contributor.groupFuncionalitat i Seguretat Alimentàriaca


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