Accumulation of C-CTX1 in Muscle Tissue of Goldfish (Carassius auratus) by Dietary Experience
Silva Sergent, Freddy
Ciguatoxins (CTXs) are produced by dinoflagellates usually present in tropical and subtropical waters. These toxins are bioaccumulated and transformed in fish causing ciguatera fish poisoning (CFP) in humans. Few trials have been performed to understand how CTXs are incorporated into fish. This study developed an experimental model of goldfish (Carassius auratus) fed flesh contaminated with Caribbean ciguatoxin (C-CTX1). Fourteen goldfish were fed 0.014 ng CTX1B (Eq. g−1 of body weight) daily, and control goldfish received non-toxic flesh. CTX presence was determined by a cell-based assay on days 1, 8, 15, 29, 36, 43, and 84. Toxicity was detected in muscle from the second sampling and then seemed to stabilize at ~0.03 ng CTX1B Eq. g−1. After two weeks, all experimental goldfish developed lethargy and loss of brightness, but only two of them displayed erratic swimming and jerking movements near the sixth sampling. One of these fish had its toxic diet replaced by commercial food for 60 more days; the fish showed recovery signs within the first weeks and no CTX activity was detected. These results indicate that C-CTX1 could accumulate in goldfish muscle tissue and produce toxic symptoms, but also remarked on the detoxification and recovery capacity of this species.
639 - Caça. Pesca. Piscicultura
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Sanchez-Henao, Andres, Natalia García-Álvarez, Daniel Padilla, María Ramos-Sosa, Freddy Silva Sergent, Antonio Fernández, Pablo Estévez, Ana Gago-Martínez, Jorge Diogène, and Fernando Real. 2021. "Accumulation Of C-CTX1 In Muscle Tissue Of Goldfish (Carassius Auratus) By Dietary Experience". Animals 11 (1): 242. doi:10.3390/ani11010242.
Grant agreement number
EFSA/ /GP-EFSA-AFSCO-2015-03/EU/Risk Characterization of Ciguatera Food Poisoning in Europe/EUROCIGUA
MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I/PID2019-108781RR-C22/ES/Ciguatoxina en la cadena alimentaria: estudio controlado de su bioacumulación en especies de peces/CIGUAFOOD
Aigües Marines i Continentals
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