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dc.contributor.authorRiahi, Insaf
dc.contributor.authorPérez‐Vendrell, Anna Maria
dc.contributor.authorRamos, Antonio J.
dc.contributor.authorBrufau, Joaquim
dc.contributor.authorEsteve‐Garcia, Enric
dc.contributor.authorSchulthess, Julie
dc.contributor.authorMarquis, Virginie
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-03-18T09:41:16Z
dc.date.available2021-03-18T09:41:16Z
dc.date.issued2021-03-17
dc.identifier.citationRiahi, Insaf, Anna Maria Pérez-Vendrell, Antonio J. Ramos, Joaquim Brufau, Enric Esteve-Garcia, Julie Schulthess, and Virginie Marquis. 2021. "Biomarkers Of Deoxynivalenol Toxicity In Chickens With Special Emphasis On Metabolic And Welfare Parameters". Toxins 13 (3): 217. doi:10.3390/toxins13030217.ca
dc.identifier.issn2072-6651ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1201
dc.description.abstractDeoxynivalenol (DON), a trichothecene mycotoxin produced by Fusarium species, is the most widespread mycotoxin in poultry feed worldwide. Long term-exposure from low to moderate DON concentrations can produce alteration in growth performance and impairment of the health status of birds. To evaluate the efficacy of mycotoxin-detoxifying agent alleviating the toxic effects of DON, the most relevant biomarkers of toxicity of DON in chickens should be firstly determined. The specific biomarker of exposure of DON in chickens is DON-3 sulphate found in different biological matrices (plasma and excreta). Regarding the nonspecific biomarkers called also biomarkers of effect, the most relevant ones are the impairment of the productive parameters, the intestinal morphology (reduction of villus height) and the enlargement of the gizzard. Moreover, the biomarkers of effect related to physiology (decrease of blood proteins, triglycerides, hemoglobin, erythrocytes, and lymphocytes and the increase of alanine transaminase (ALT)), immunity (response to common vaccines and release of some proinflammatory cytokines) and welfare status of the birds (such as the increase of Thiobarbituric acid reactive substances (TBARS) and the stress index), has been reported. This review highlights the available information regarding both types of biomarkers of DON toxicity in chickens.ca
dc.format.extent28ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofToxinsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleBiomarkers of Deoxynivalenol Toxicity in Chickens with Special Emphasis on Metabolic and Welfare Parametersca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc63ca
dc.identifier.doihttps://doi.org/10.3390/toxins13030217ca
dc.contributor.groupNutrició Animalca


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