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dc.contributor.authorBovo, Samuele
dc.contributor.authorSchiavo, Giuseppina
dc.contributor.authorRibani, Anisa
dc.contributor.authorUtzeri, Valerio J.
dc.contributor.authorTaurisano, Valeria
dc.contributor.authorBallan, Mohamad
dc.contributor.authorMuñoz, Maria
dc.contributor.authorAlves, Estefania
dc.contributor.authorAraujo, Jose P.
dc.contributor.authorBozzi, Riccardo
dc.contributor.authorCharneca, Rui
dc.contributor.authorDi Palma, Federica
dc.contributor.authorDjurkin Kušec, Ivona
dc.contributor.authorEtherington, Graham
dc.contributor.authorFernandez, Ana I.
dc.contributor.authorGarcía, Fabián
dc.contributor.authorGarcía-Casco, Juan
dc.contributor.authorKarolyi, Danijel
dc.contributor.authorGallo, Maurizio
dc.contributor.authorMartins, José Manuel
dc.contributor.authorMercat, Marie-José
dc.contributor.authorNúñez, Yolanda
dc.contributor.authorQuintanilla, Raquel
dc.contributor.authorRadović, Čedomir
dc.contributor.authorRazmaite, Violeta
dc.contributor.authorRiquet, Juliette
dc.contributor.authorSavić, Radomir
dc.contributor.authorŠkrlep, Martin
dc.contributor.authorUsai, Graziano
dc.contributor.authorZimmer, Christoph
dc.contributor.authorOvilo, Cristina
dc.contributor.authorFontanesi, Luca
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-05-12T16:57:20Z
dc.date.available2021-05-12T16:57:20Z
dc.date.issued2021-02-09
dc.identifier.citationBovo, Samuele, Giuseppina Schiavo, Anisa Ribani, Valerio J. Utzeri, Valeria Taurisano, Mohamad Ballan, and Maria Muñoz et al. 2021. "Describing Variability In Pig Genes Involved In Coronavirus Infections For A One Health Perspective In Conservation Of Animal Genetic Resources". Scientific Reports 11 (1). doi:10.1038/s41598-021-82956-0.ca
dc.identifier.issn2045-2322ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1253
dc.description.abstractCoronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a “One Health” perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources.ca
dc.format.extent14ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofScientific Reportsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleDescribing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resourcesca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDEC/H2020/634476/EU/DIVERSITY OF LOCAL PIG BREEDS AND PRODUCTION SYSTEMS FOR HIGH QUALITY TRADITIONAL PRODUCTS AND SUSTAINABLE PORK CHAINS/TREASUREca
dc.relation.projectIDEC/COST/CA15112/EU/Functional Annotation of Animal Genomes-European network/FAANG-Europeca
dc.relation.projectIDEC/H2020/831644/EU/EOSCsecretariat.eu/EOSCsecretariat.euca
dc.relation.projectIDEC/ / /EU/Application of animal genomics and data mining to predict and monitor novel coronavirus potential infections/VirAnimalOneca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.1038/s41598-021-82956-0ca
dc.contributor.groupGenètica i Millora Animalca


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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