Mostra el registre parcial de l'element
Transmission of Similar Mcr-1 Carrying Plasmids among Different Escherichia coli Lineages Isolated from Livestock and the Farmer
dc.contributor.author | Viñes, Joaquim | |
dc.contributor.author | Cuscó, Anna | |
dc.contributor.author | Napp, Sebastian | |
dc.contributor.author | Alvarez, Julio | |
dc.contributor.author | Saez-Llorente, Jose Luis | |
dc.contributor.author | Rosàs-Rodoreda, Montserrat | |
dc.contributor.author | Francino, Olga | |
dc.contributor.author | Migura-Garcia, Lourdes | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2021-05-18T11:45:38Z | |
dc.date.available | 2021-05-18T11:45:38Z | |
dc.date.issued | 2021-03-17 | |
dc.identifier.citation | Viñes, Joaquim, Anna Cuscó, Sebastian Napp, Julio Alvarez, Jose Luis Saez-Llorente, Montserrat Rosàs-Rodoreda, Olga Francino, and Lourdes Migura-Garcia. 2021. "Transmission Of Similar Mcr-1 Carrying Plasmids Among Different Escherichia Coli Lineages Isolated From Livestock And The Farmer". Antibiotics 10 (3): 313. doi:10.3390/antibiotics10030313. | ca |
dc.identifier.issn | 2079-6382 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1266 | |
dc.description.abstract | Colistin use has mostly been stopped in human medicine, due to its toxicity. However, nowadays, it still is used as a last-resort antibiotic to treat hospital infections caused by multi-drug resistant Enterobacteriaceae. On the contrary, colistin has been used in veterinary medicine until recently. In this study, 210 fecal samples from pigs (n = 57), calves (n = 152), and the farmer (n = 1) were collected from a farm where E. coli harboring mcr-1-mcr-3 was previously detected. Samples were plated, and mcr-genes presence was confirmed by multiplex-PCR. Hybrid sequencing which determined the presence and location of mcr-1, other antibiotic resistance genes, and virulence factors. Eighteen colistin resistant isolates (13 from calves, four from pigs, and one from the farmer) contained mcr-1 associated with plasmids (IncX4, IncI2, and IncHI2), except for two that yielded mcr-1 in the chromosome. Similar plasmids were distributed in different E. coli lineages. Transmission of mcr-1 to the farmer most likely occurred by horizontal gene transfer from E. coli of calf origin, since plasmids were highly similar (99% coverage, 99.97% identity). Moreover, 33 virulence factors, including stx2 for Shiga toxin E. coli (STEC) were detected, highlighting the role of livestock as a reservoir of pathotypes with zoonotic potential. | ca |
dc.format.extent | 13 | ca |
dc.language.iso | eng | ca |
dc.publisher | MDPI | ca |
dc.relation.ispartof | Antibiotics | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Transmission of Similar Mcr-1 Carrying Plasmids among Different Escherichia coli Lineages Isolated from Livestock and the Farmer | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | MINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/RTI2018-095586-B-C22/ES/Optimization of diagnosis and treatment of postweaning diarrheas in pigs: towards a rational use of antibiotics/ | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.3390/antibiotics10030313 | ca |
dc.contributor.group | Sanitat Animal | ca |
Fitxers en aquest element
Aquest element apareix en la col·lecció o col·leccions següent(s)
-
ARTICLES CIENTÍFICS [2.831]