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dc.contributor.authorBarrio, Tomás
dc.contributor.authorVidal, Enric
dc.contributor.authorBetancor, Marina
dc.contributor.authorOtero, Alicia
dc.contributor.authorMartín-Burriel, Inmaculada
dc.contributor.authorMonzón, Marta
dc.contributor.authorMonleón, Eva
dc.contributor.authorPumarola, Martí
dc.contributor.authorBadiola, Juan José
dc.contributor.authorBolea, Rosa
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-06-10T11:33:36Z
dc.date.available2021-06-10T11:33:36Z
dc.date.issued2021-03-08
dc.identifier.citationBarrio, Tomás, Enric Vidal, Marina Betancor, Alicia Otero, Inmaculada Martín-Burriel, Marta Monzón, Eva Monleón, Martí Pumarola, Juan José Badiola, and Rosa Bolea. 2021. "Evidence Of P75 Neurotrophin Receptor Involvement In The Central Nervous System Pathogenesis Of Classical Scrapie In Sheep And A Transgenic Mouse Model". International Journal Of Molecular Sciences 22 (5): 2714. doi:10.3390/ijms22052714.ca
dc.identifier.issn1661-6596ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1285
dc.description.abstractNeurotrophins constitute a group of growth factor that exerts important functions in the nervous system of vertebrates. They act through two classes of transmembrane receptors: tyrosine-kinase receptors and the p75 neurotrophin receptor (p75NTR). The activation of p75NTR can favor cell survival or apoptosis depending on diverse factors. Several studies evidenced a link between p75NTR and the pathogenesis of prion diseases. In this study, we investigated the distribution of several neurotrophins and their receptors, including p75NTR, in the brain of naturally scrapie-affected sheep and experimentally infected ovinized transgenic mice and its correlation with other markers of prion disease. No evident changes in infected mice or sheep were observed regarding neurotrophins and their receptors except for the immunohistochemistry against p75NTR. Infected mice showed higher abundance of p75NTR immunostained cells than their non-infected counterparts. The astrocytic labeling correlated with other neuropathological alterations of prion disease. Confocal microscopy demonstrated the co-localization of p75NTR and the astrocytic marker GFAP, suggesting an involvement of astrocytes in p75NTR-mediated neurodegeneration. In contrast, p75NTR staining in sheep lacked astrocytic labeling. However, digital image analyses revealed increased labeling intensities in preclinical sheep compared with non-infected and terminal sheep in several brain nuclei. This suggests that this receptor is overexpressed in early stages of prion-related neurodegeneration in sheep. Our results confirm a role of p75NTR in the pathogenesis of classical ovine scrapie in both the natural host and in an experimental transgenic mouse model.ca
dc.format.extent18ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofInternational Journal of Molecular Sciencesca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleEvidence of p75 Neurotrophin Receptor Involvement in the Central Nervous System Pathogenesis of Classical Scrapie in Sheep and a Transgenic Mouse Modelca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO/Programa Estatal de I + D + I orientada a los retos de la sociedad/AGL2015-65560-R/ES/Implicación de la glicosilación en la transmisión de las enfermedades priónicas, biomarcadores moleculares y papel de las neurotrofinas en la neurodegeneración/ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.3390/ijms22052714ca
dc.contributor.groupSanitat Animalca


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