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dc.contributor.authorCatalán-García, Marc
dc.contributor.authorChauvigné, François
dc.contributor.authorStavang, Jon Anders
dc.contributor.authorNilsen, Frank
dc.contributor.authorCerdà, Joan
dc.contributor.authorFinn, Roderick Nigel
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-07-07T16:32:06Z
dc.date.available2021-07-07T16:32:06Z
dc.date.issued2021-05-31
dc.identifier.citationCatalán-García, Marc, François Chauvigné, Jon Anders Stavang, Frank Nilsen, Joan Cerdà, and Roderick Nigel Finn. 2021. "Lineage-Level Divergence Of Copepod Glycerol Transporters And The Emergence Of Isoform-Specific Trafficking Regulation". Communications Biology 4 (1). doi:10.1038/s42003-021-01921-9.ca
dc.identifier.issn2399-3642ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1311
dc.description.abstractTransmembrane conductance of small uncharged solutes such as glycerol typically occurs through aquaglyceroporins (Glps), which are commonly encoded by multiple genes in metazoan organisms. To date, however, little is known concerning the evolution of Glps in Crustacea or what forces might underly such apparent gene redundancy. Here, we show that Glp evolution in Crustacea is highly divergent, ranging from single copy genes in species of pedunculate barnacles, tadpole shrimps, isopods, amphipods and decapods to up to 10 copies in diplostracan water fleas although with monophyletic origins in each lineage. By contrast the evolution of Glps in Copepoda appears to be polyphyletic, with surprisingly high rates of gene duplication occurring in a genera- and species-specific manner. Based upon functional experiments on the Glps from a parasitic copepod (Lepeophtheirus salmonis), we show that such lineage-level gene duplication and splice variation is coupled with a high rate of neofunctionalization. In the case of L. salmonis, splice variation of a given gene resulted in tissue- or sex-specific expression of the channels, with each variant evolving unique sites for protein kinase C (PKC)- or protein kinase A (PKA)-regulation of intracellular membrane trafficking. The combined data sets thus reveal that mutations favouring a high fidelity control of intracellular trafficking regulation can be a selection force for the evolution and retention of multiple Glps in copepods.ca
dc.format.extent14ca
dc.language.isoengca
dc.publisherNature Researchca
dc.relation.ispartofCommunications Biologyca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleLineage-level divergence of copepod glycerol transporters and the emergence of isoform-specific trafficking regulationca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I/PID2019-103868RB-I00/ES/Ingeniería de proteínas dirigidas a las vesículas: un nuevo enfoque biotecnológico para la criopreservación de oocitos y embriones de peces/CRYOYOLKca
dc.relation.projectIDMINECO/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC-2015-17103/ES/ /ca
dc.subject.udc639ca
dc.identifier.doihttps://doi.org/10.1038/s42003-021-01921-9ca
dc.contributor.groupAqüiculturaca


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