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dc.contributor.authorRiahi, Insaf
dc.contributor.authorRamos, Antonio J.
dc.contributor.authorPÉREZ-VENDRELL, ANNA MARIA
dc.contributor.authorMarquis, Virginie
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-07-29T08:04:30Z
dc.date.available2021-07-29T08:04:30Z
dc.date.issued2021-06-26
dc.identifier.citationRiahi, Insaf, Antonio J. Ramos, Anna Maria Pérez-Vendrell, and Virginie Marquis. 2021. "A Toxicokinetic Study Reflecting The Absorption, Distribution, Metabolism And Excretion Of Deoxynivalenol In Broiler Chickens". Journal Of Applied Animal Research 49 (1): 284-288. doi:10.1080/09712119.2021.1946403.ca
dc.identifier.issn0971-2119ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1325
dc.description.abstractTo identify the specific biomarkers of exposure of DON in chickens, a toxicokinetic study was performed via oral or intravenous application of deoxynivalenol (DON). Doses of 0.75 and 2.25 mg DON/kg of body weight (BW) were administrated intravenously or orally to the chickens. Next, blood samples were ollected at several time points and plasma was obtained. Liquid chromatography–tandem mass-spectrometry (LC–MS/MS) was used to quantify plasma levels of DON and its metabolite DON-3-sulphate (DON-3S). A non-compartmental analysis was performed to study the main toxicokinetic parameters after intravenous or oral application of the toxin. Regarding oral administration, DON plasma level was below the limit of detection (LOD) of the method (1.5 ng/mL) and DON-3S could not be identified. After intravenous administration of DON at 0.75 and 2.25 mg DON/kg BW, the elimination half-life was 57.1 and 47.7 min, respectively, indicating the rapid elimination of DON. The metabolite DON-3S was found in plasma of broilers exposed to DON intravenously. The absence of DON in chicken plasma after oral bolus application suggests the low absorption of this mycotoxin. The presence of DON-3S in plasma indicates that this metabolite could be the appropriate biomarker of DON exposure in chickens.ca
dc.format.extent6ca
dc.language.isoengca
dc.publisherTaylor & Francis Open Accessca
dc.relation.ispartofJournal of Applied Animal Researchca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleA toxicokinetic study reflecting the absorption, distribution, metabolism and excretion of deoxynivalenol in broiler chickensca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc636ca
dc.identifier.doihttps://doi.org/10.1080/09712119.2021.1946403ca
dc.contributor.groupNutrició Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/