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Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster
dc.contributor.author | Brustolin, Marco | |
dc.contributor.author | Rodon, Jordi | |
dc.contributor.author | Rodríguez de la Concepción, María Luisa | |
dc.contributor.author | Ávila-Nieto, Carlos | |
dc.contributor.author | Cantero, Guillermo | |
dc.contributor.author | Pérez, Mónica | |
dc.contributor.author | Te, Nigeer | |
dc.contributor.author | Noguera-Julián, Marc | |
dc.contributor.author | Guallar, Víctor | |
dc.contributor.author | Valencia, Alfonso | |
dc.contributor.author | Roca, Núria | |
dc.contributor.author | Izquierdo-Useros, Nuria | |
dc.contributor.author | Blanco, Julià | |
dc.contributor.author | Clotet, Bonaventura | |
dc.contributor.author | Bensaid, Albert | |
dc.contributor.author | Carrillo, Jorge | |
dc.contributor.author | Vergara-Alert, Júlia | |
dc.contributor.author | Segalés, Joaquim | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2021-09-23T12:41:59Z | |
dc.date.available | 2021-09-23T12:41:59Z | |
dc.date.issued | 2021-04-29 | |
dc.identifier.citation | Brustolin, Marco, Jordi Rodon, María Luisa Rodríguez de la Concepción, Carlos Ávila-Nieto, Guillermo Cantero, Mónica Pérez, and Nigeer Te et al. 2021. "Protection Against Reinfection With D614- Or G614-SARS-Cov-2 Isolates In Golden Syrian Hamster". Emerging Microbes & Infections 10 (1): 797-809. doi:10.1080/22221751.2021.1913974. | ca |
dc.identifier.issn | 2222-1751 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1343 | |
dc.description.abstract | Reinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by a single infection is sufficient to provide sterilizing/protective immunity to a subsequent SARS-CoV-2 re-exposure. The Golden Syrian hamster is a manageable animal model to explore immunological mechanisms able to counteract COVID-19, as it recapitulates pathological aspects of mild to moderately affected patients. Here, we report that SARS-CoV-2-inoculated hamsters resolve infection in the upper and lower respiratory tracts within seven days upon inoculation with the Cat01 (G614) SARS-CoV-2 isolate. Three weeks after the primary challenge, and despite high titres of neutralizing antibodies, half of the animals were susceptible to reinfection by both identical (Cat01, G614) and variant (WA/1, D614) SARS-CoV-2 isolates. However, upon re-inoculation, only nasal tissues were transiently infected with much lower viral replication than those observed after the first inoculation. These data indicate that a primary SARS-CoV-2 infection is not sufficient to elicit a sterilizing immunity in hamster models but protects against lung disease. | ca |
dc.format.extent | 14 | ca |
dc.language.iso | eng | ca |
dc.publisher | Taylor & Francis Open Access | ca |
dc.relation.ispartof | Emerging Microbes and Infections | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Protection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamster | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1080/22221751.2021.1913974 | ca |
dc.contributor.group | Sanitat Animal | ca |
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