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dc.contributor.authorBrustolin, Marco
dc.contributor.authorRodon, Jordi
dc.contributor.authorRodríguez de la Concepción, María Luisa
dc.contributor.authorÁvila-Nieto, Carlos
dc.contributor.authorCantero, Guillermo
dc.contributor.authorPérez, Mónica
dc.contributor.authorTe, Nigeer
dc.contributor.authorNoguera-Julián, Marc
dc.contributor.authorGuallar, Víctor
dc.contributor.authorValencia, Alfonso
dc.contributor.authorRoca, Núria
dc.contributor.authorIzquierdo-Useros, Nuria
dc.contributor.authorBlanco, Julià
dc.contributor.authorClotet, Bonaventura
dc.contributor.authorBensaid, Albert
dc.contributor.authorCarrillo, Jorge
dc.contributor.authorVergara-Alert, Júlia
dc.contributor.authorSegalés, Joaquim
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-09-23T12:41:59Z
dc.date.available2021-09-23T12:41:59Z
dc.date.issued2021-04-29
dc.identifier.citationBrustolin, Marco, Jordi Rodon, María Luisa Rodríguez de la Concepción, Carlos Ávila-Nieto, Guillermo Cantero, Mónica Pérez, and Nigeer Te et al. 2021. "Protection Against Reinfection With D614- Or G614-SARS-Cov-2 Isolates In Golden Syrian Hamster". Emerging Microbes & Infections 10 (1): 797-809. doi:10.1080/22221751.2021.1913974.ca
dc.identifier.issn2222-1751ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1343
dc.description.abstractReinfections with SARS-CoV-2 have already been documented in humans, although its real incidence is currently unknown. Besides having a great impact on public health, this phenomenon raises the question of immunity generated by a single infection is sufficient to provide sterilizing/protective immunity to a subsequent SARS-CoV-2 re-exposure. The Golden Syrian hamster is a manageable animal model to explore immunological mechanisms able to counteract COVID-19, as it recapitulates pathological aspects of mild to moderately affected patients. Here, we report that SARS-CoV-2-inoculated hamsters resolve infection in the upper and lower respiratory tracts within seven days upon inoculation with the Cat01 (G614) SARS-CoV-2 isolate. Three weeks after the primary challenge, and despite high titres of neutralizing antibodies, half of the animals were susceptible to reinfection by both identical (Cat01, G614) and variant (WA/1, D614) SARS-CoV-2 isolates. However, upon re-inoculation, only nasal tissues were transiently infected with much lower viral replication than those observed after the first inoculation. These data indicate that a primary SARS-CoV-2 infection is not sufficient to elicit a sterilizing immunity in hamster models but protects against lung disease.ca
dc.format.extent14ca
dc.language.isoengca
dc.publisherTaylor & Francis Open Accessca
dc.relation.ispartofEmerging Microbes and Infectionsca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleProtection against reinfection with D614- or G614-SARS-CoV-2 isolates in golden Syrian hamsterca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.1080/22221751.2021.1913974ca
dc.contributor.groupSanitat Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/