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dc.contributor.authorLópez-Serrano, Sergi
dc.contributor.authorNeila-Ibáñez, Carlos
dc.contributor.authorCosta-Hurtado, Mar
dc.contributor.authorMahmmod, Yasser
dc.contributor.authorMartínez-Martínez, Jorge
dc.contributor.authorGalindo-Cardiel, Iván José
dc.contributor.authorDarji, Ayub
dc.contributor.authorRodríguez, Fernando
dc.contributor.authorSibila, Marina
dc.contributor.authorAragon, Virginia
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-09-28T09:15:44Z
dc.date.available2021-09-28T09:15:44Z
dc.date.issued2021-05-20
dc.identifier.citationLópez-Serrano, Sergi, Carlos Neila-Ibáñez, Mar Costa-Hurtado, Yasser Mahmmod, Jorge Martínez-Martínez, Iván José Galindo-Cardiel, Ayub Darji, Fernando Rodríguez, Marina Sibila, and Virginia Aragon. 2021. "Sow Vaccination With A Protein Fragment Against Virulent Glaesserella (Haemophilus) Parasuis Modulates Immunity Traits In Their Offspring". Vaccines 9 (5): 534. doi:10.3390/vaccines9050534.ca
dc.identifier.issn2076-393Xca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1352
dc.description.abstractGlaesserella (Haemophilus) parasuis, an early colonizer of the nasal cavity in piglets, is a highly heterogeneous species, comprising both commensal and virulent strains. Virulent G. parasuis strains can cause fibrinous polyserositis called Glässer's disease. Colostrum is a source of passive immunity for young piglets. When vaccinating sows, protective antibodies are transferred to their offspring through the colostrum. Here, sow vaccination was performed with a protein fragment, F4, from the outer membrane trimeric autotransporters VtaAs exclusively found in virulent G. parasuis. Piglets were allowed to suckle for 3 weeks, following which a challenge with two virulent strains of G. parasuis was performed. A group of nonvaccinated sows and their piglets were included as a control. Antibodies against F4 were confirmed using ELISA in the vaccinated sows and their offspring before the G. parasuis challenge. Compared to the control group, F4-vaccination also resulted in an increased level of serum TGF-β both in vaccinated sows and in their offspring at early time points of life. After the challenge, a lower body temperature and a higher weight were observed in the group of piglets from vaccinated sows. One piglet from the non-vaccinated group succumbed to the infection, but no other significant differences in clinical signs were noticed. At necropsy, performed 2 weeks after the virulent challenge, the level of surfactant protein D (SP-D) in bronchoalveolar lavage was higher in the piglets from vaccinated sows. Vaccination did not inhibit the nasal colonization of the piglets by the challenge strains.ca
dc.format.extent14ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofVaccinesca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleSow Vaccination with a Protein Fragment against Virulent Glaesserella (Haemophilus) parasuis Modulates Immunity Traits in Their Offspringca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO/Programa Estatal de I+D+I orientada a los retos de la Sociedad/AGL2016-77361-R/ES/PAPEL DE LA MICROBIOTA RESPIRATORIA EN LA PREVENCION DE LAS ENFERMEDADES CAUSADAS POR LOS COLONIZADORES PRECOCES DEL TRACTO RESPIRATORIO SUPERIOR DEL CERDO/ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.3390/vaccines9050534ca
dc.contributor.groupSanitat Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/