Early and Solid Protection Afforded by the Thiverval Vaccine Provides Novel Vaccination Alternatives Against Classical Swine Fever Virus
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Author
Lamothe-Reyes, Yaneysis
Bohórquez, José Alejandro
Wang, Miaomiao
Alberch, Mònica
Pérez-Simó, Marta
Publication date
2021-05-06ISSN
2076-393X
Abstract
Classical swine fever virus (CSFV) remains a challenge for the porcine industry. Inefficient
vaccination programs in some endemic areas may have contributed to the emergence of low and
moderate virulence CSFV variants. This work aimed to expand and update the information about the
safety and efficacy of the CSFV Thiverval-strain vaccine. Two groups of pigs were vaccinated, and
a contact and control groups were also included. Animals were challenged with a highly virulent
CSFV strain at 21- or 5-days post vaccination (dpv). The vaccine induced rapid and strong IFN-α
response, mainly in the 5-day immunized group, and no vaccine virus transmission was detected.
Vaccinated pigs showed humoral response against CSFV E2 and Erns glycoproteins, with neutralising
activity, starting at 14 days post vaccination (dpv). Strong clinical protection was afforded in all the
vaccinated pigs as early as 5 dpv. The vaccine controlled viral replication after challenge, showing
efficient virological protection in the 21-day immunized pigs despite being housed with animals
excreting high CSFV titres. These results demonstrate the high efficacy of the Thiverval strain against
CSFV replication. Its early protection capacity makes it a useful alternative for emergency vaccination
and a consistent tool for CSFV control worldwide.
Document Type
Article
Document version
Published version
Language
English
Subject (CDU)
619 - Veterinary science
Pages
14
Publisher
MDPI
Is part of
Vaccines
Citation
Lamothe-Reyes, Yaneysis, José Alejandro Bohórquez, Miaomiao Wang, Mònica Alberch, Marta Pérez-Simó, Rosa Rosell, and Llilianne Ganges. 2021. "Early And Solid Protection Afforded By The Thiverval Vaccine Provides Novel Vaccination Alternatives Against Classical Swine Fever Virus". Vaccines 9 (5): 464. doi:10.3390/vaccines9050464.
Grant agreement number
MINECO/Programa estatal de I+D+I orientada a los retos de la sociedad/RTI2018-100887-B-100/ES/Descifrando nuevos factores virales y del hospedador involucrados en el desarrollo de la peste porcina clásica: implicaciones para el control de la enfermedad/
Program
Sanitat Animal
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2646]
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/