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dc.contributor.authorBosch-Camós, Laia
dc.contributor.authorLópez, Elisabet
dc.contributor.authorCollado, Javier
dc.contributor.authorNavas, María J.
dc.contributor.authorBlanco-Fuertes, Miguel
dc.contributor.authorPina-Pedrero, Sonia
dc.contributor.authorAccensi, Francesc
dc.contributor.authorSalas, Maria Luisa
dc.contributor.authorMundt, Egbert
dc.contributor.authorNikolin, Veljko
dc.contributor.authorRodríguez, Fernando
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-09-28T12:32:42Z
dc.date.available2021-09-28T12:32:42Z
dc.date.issued2021-05-14
dc.identifier.citationBosch-Camós, Laia, Elisabet López, Javier Collado, María J. Navas, Miguel Blanco-Fuertes, Sonia Pina-Pedrero, and Francesc Accensi et al. 2021. "M448R And MGF505-7R: Two African Swine Fever Virus Antigens Commonly Recognized By ASFV-Specific T-Cells And With Protective Potential". Vaccines 9 (5): 508. https://www.mdpi.com/2076-393X/9/5/508/htm.ca
dc.identifier.issn2076-393Xca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1361
dc.description.abstractAfrican swine fever (ASF) is today′s number one threat for the global swine industry. Neither commercial vaccine nor treatment is available against ASF and, thus far, only live attenuated viruses (LAV) have provided robust protection against lethal ASF virus (ASFV) challenge infections. Identification of ASFV proteins inducing protective immune responses is one of the major challenges to develop safer and efficient subunit vaccines. Immunopeptidomic studies recently performed in our laboratory allowed identifying ASFV antigens recognized by ASFV-specific CD8+ T-cells. Here, we used data from the SLAI-peptide repertoire presented by a single set of ASFV-infected porcine alveolar macrophages to generate a complex DNA vaccine composed by 15 plasmids encoding the individual peptide-bearing ORFs. DNA vaccine priming improved the protection afforded by a suboptimal dose of the BA71ΔCD2 LAV given as booster vaccination, against Georgia2007/1 lethal challenge. Interestingly, M448R was the only protein promiscuously recognized by the induced ASFV-specific T-cells. Furthermore, priming pigs with DNA plasmids encoding M488R and MGF505-7R, a CD8+ T-cell antigen previously described, confirmed these two proteins as T-cell antigens with protective potential. These studies might be useful to pave the road for designing safe and more efficient vaccine formulations in the future.ca
dc.format.extent16ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofVaccinesca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleM448R and MGF505-7R: Two African Swine Fever Virus Antigens Commonly Recognized by ASFV-Specific T-Cells and with Protective Potentialca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2016-78160-C2-1-R/ES/Estrategias de protección frente a la peste porcina africana: de la investigación básica a la aplicada/ca
dc.relation.projectIDMICIU/Programas Estatales de Generación de Conocimiento y Fortalecimiento Científico y Tecnológico del Sistema de I+D+i y de I+D+i Orientada a los Retos de la Sociedad/PID2019-107616RB-I00/ES/Peste porcina africana; de la emergencia a evitar el endemismo/ca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.3390/vaccines9050508ca
dc.contributor.groupSanitat Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/