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dc.contributor.authorTrinité, Benjamin
dc.contributor.authorPradenas, Edwards
dc.contributor.authorMarfil, Silvia
dc.contributor.authorRovirosa, Carla
dc.contributor.authorUrrea, Víctor
dc.contributor.authorTarrés-Freixas, Ferran
dc.contributor.authorOrtiz, Raquel
dc.contributor.authorRodon, Jordi
dc.contributor.authorVergara-Alert, Júlia
dc.contributor.authorSegalés, Joaquim
dc.contributor.authorGuallar, Victor
dc.contributor.authorLepore, Rosalba
dc.contributor.authorIzquierdo-Useros, Nuria
dc.contributor.authorTrujillo, Glòria
dc.contributor.authorTrapé, Jaume
dc.contributor.authorGonzález-Fernández, Carolina
dc.contributor.authorFlor, Antonia
dc.contributor.authorPérez-Vidal, Rafel
dc.contributor.authorToledo, Ruth
dc.contributor.authorChamorro, Anna
dc.contributor.authorParedes, Roger
dc.contributor.authorBlanco, Ignacio
dc.contributor.authorGrau, Eulàlia
dc.contributor.authorMassanella, Marta
dc.contributor.authorCarrillo, Jorge
dc.contributor.authorClotet, Bonaventura
dc.contributor.authorBlanco, Julià
dc.contributor.otherProducció Animalca
dc.date.accessioned2021-11-23T10:07:41Z
dc.date.available2021-11-23T10:07:41Z
dc.date.issued2021-06-12
dc.identifier.citationTrinité, Benjamin, Edwards Pradenas, Silvia Marfil, Carla Rovirosa, Víctor Urrea, Ferran Tarrés-Freixas, and Raquel Ortiz et al. 2021. "Previous SARS-Cov-2 Infection Increases B.1.1.7 Cross-Neutralization By Vaccinated Individuals". Viruses 13 (6): 1135. doi:10.3390/v13061135.ca
dc.identifier.issn1999-4915ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1411
dc.description.abstractWith the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection.ca
dc.format.extent12ca
dc.language.isoengca
dc.publisherMDPIca
dc.relation.ispartofVirusesca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePrevious SARS-CoV-2 Infection Increases B.1.1.7 Cross-Neutralization by Vaccinated Individualsca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.subject.udc619ca
dc.identifier.doihttps://doi.org/10.3390/v13061135ca
dc.contributor.groupSanitat Animalca


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Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/