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dc.contributor.authorRambla-Alegre, Maria
dc.contributor.authorMiles, Christopher O.
dc.contributor.authorde la Iglesia, Pablo
dc.contributor.authorFernandez-Tejedor, Margarita
dc.contributor.authorJacobs, Silke
dc.contributor.authorSioen, Isabelle
dc.contributor.authorVerbeke, Wim
dc.contributor.authorSamdal, Ingunn A.
dc.contributor.authorSandvik, Morten
dc.contributor.authorBarbosa, Vera
dc.contributor.authorTediosi, Alice
dc.contributor.authorMadorran, Eneko
dc.contributor.authorGranby, Kit
dc.contributor.authorKotterman, Michiel
dc.contributor.authorCalis, Tanja
dc.contributor.authorDiogene, Jorge
dc.contributor.otherProducció Animalca
dc.date.accessioned2019-01-04T11:55:04Z
dc.date.available2019-12-01T23:01:19Z
dc.date.issued2017-12-01
dc.identifier.citationRambla-Alegre, Maria, Christopher O. Miles, Pablo de la Iglesia, Margarita Fernandez-Tejedor, Silke Jacobs, Isabelle Sioen, and Wim Verbeke et al. 2018. "Occurrence Of Cyclic Imines In European Commercial Seafood And Consumers Risk Assessment". Environmental Research 161: 392-398. Elsevier BV. doi:10.1016/j.envres.2017.11.028.ca
dc.identifier.issn0013-9351ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/146
dc.description.abstractCyclic imines constitute a quite recently discovered group of marine biotoxins that act on neural receptors and that bioaccumulate in seafood. They are grouped together due to the imino group functioning as their common pharmacore, responsible for acute neurotoxicity in mice. Cyclic imines (CIs) have not been linked yet to human poisoning and are not regulated in the European Union (EU), although the European Food Safety Authority (EFSA) requires more data to perform conclusive risk assessment for consumers. Several commercial samples of bivalves including raw and processed samples from eight countries (Italy, Portugal, Slovenia, Spain, Ireland, Norway, The Netherlands and Denmark) were obtained over 2 years. Emerging cyclic imine concentrations in all the samples were analysed on a LC-3200QTRAP and LC-HRMS QExactive mass spectrometer. In shellfish, two CIs, pinnatoxin G (PnTX-G) and 13-desmethylspirolide C (SPX-1) were found at low concentrations (0.1–12 µg/kg PnTX-G and 26–66 µg/kg SPX-1), while gymnodimines and pteriatoxins were not detected in commercial (raw and processed) samples. In summary, SPX-1 (n: 47) and PnTX-G (n: 96) were detected in 9.4% and 4.2% of the samples, respectively, at concentrations higher than the limit of quantification (LOQ), and in 7.3% and 31.2% of the samples at concentrations lower than the LOQ (25 µg/kg for SPX-1 and 3 µg/kg for PnTX-G), respectively. For the detected cyclic imines, the average exposure and the 95th percentile were calculated. The results obtained indicate that it is unlikely that a potential health risk exists through the seafood diet for CIs in the EU. However, further information about CIs is necessary in order to perform a conclusive risk assessment.ca
dc.format.extent20ca
dc.language.isoengca
dc.publisherElsevierca
dc.relation.ispartofEnvironmental Researchca
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleOccurrence of cyclic imines in European commercial seafood and consumers risk assessmentca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/acceptedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.relation.projectIDEU/FP7/311820/EU/Priority environmental contaminants in seafood: safety assessment, impact and public perception/ECsafeSEAFOODca
dc.relation.projectIDINIA/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RTA2013-00096-00-00/ES/Promoción de una acuicultura de bivalvos y pesqueria sostenible y segura mediante modelizacióin y caracterización del riesgo de toxinas emergentes/PROMAQUAca
dc.subject.udc574 - Ecologia general i biodiversitatca
dc.identifier.doihttps://doi.org/10.1016/j.envres.2017.11.028ca
dc.contributor.groupAigües Marines i Continentalsca


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