Comparative Genomics Used to Predict Virulence Factors and Metabolic Genes among Monilinia Species
De Cal, Antonieta
Van Kan, Jan A. L.
Brown rot, caused by Monilinia spp., is among the most important diseases in stonefruits, and some pome fruits (mainly apples). This disease is responsible for significant yield losses,particularly in stone fruits, when weather conditions favorable for disease development appear.To achieve future sustainable strategies to control brown rot on fruit, one potential approach will be to characterize genomic variation among Monilinia spp. to define, among others, the capacity to infect fruit in this genus. In the present work, we performed genomic and phylogenomic comparisons of five Monilinia species and inferred differences in numbers of secreted proteins, including CAZy proteins and other proteins important for virulence. Duplications specific to Monilinia were sparse and, overall, more genes have been lost than gained. Among Monilinia spp., low variability in the CAZome was observed. Interestingly, we identified several secondary metabolism clusters based on similarity to known clusters, and among them was a cluster with homology to pyriculol that could be responsible for the synthesis of chloromonilicin. Furthermore, we compared sequences of all strains available from NCBI of these species to assess their MAT loci and heterokaryon Compatibility systems. Our comparative analyses provide the basis for future studies into understanding how these genomic differences underlie common or differential abilities to interact with the host plant.
633 - Cultius i produccions
Is part of
Journal of Fungi (JoF)
Marcet-Houben, Marina, Maria Villarino, Laura Vilanova, Antonieta De Cal, Jan A. L. van Kan, Josep Usall, Toni Gabaldón, and Rosario Torres. 2021. "Comparative Genomics Used To Predict Virulence Factors And Metabolic Genes Among Monilinia Species". Journal Of Fungi 7 (6): 464. doi:10.3390/jof7060464.
Grant agreement number
EC/H2020/741964/EU/The role of necrotrophic effectors in the ability of Botrytis and Monilinia species to infect host plants/NECROFUNGI
EC/H2020/724173/EU/Reticulate evolution: patterns and impacts of non-vertical inheritance in eukaryotic genomes/RETVOLUTION
EC/H2020/801370/EU/Beatriu de Pinos-3 Postdoctoral Programme/BP3
MICIU-FEDER/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I/PGC2018-099921-B-I00/ES/EVOLUCION GENOMICA Y FENOTIPICA EN PATOGENOS DEL GENERO CANDIDA/
MINECO-FEDER/Programa Estatal de I+D+I orientada a los retos de la sociedad/AGL2017-84389/ES/PODREDUMBRE PARDA CAUSADA POR MONILINIA SPP EN FRUTA DE HUESO: INTERACCION HUESPED-PATOGENO-AMBIENTE/
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- ARTICLES CIENTÍFICS 
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