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Critical Presentation of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection: A Case Report
dc.contributor.author | Massanella, Marta | |
dc.contributor.author | Martin-Urda, Anabel | |
dc.contributor.author | Mateu, Lourdes | |
dc.contributor.author | Marín, Toni | |
dc.contributor.author | Aldas, Irene | |
dc.contributor.author | Riveira-Muñoz, Eva | |
dc.contributor.author | Kipelainen, Athina | |
dc.contributor.author | Jiménez-Moyano, Esther | |
dc.contributor.author | Rodriguez de la Concepción, Maria Luisa | |
dc.contributor.author | Avila-Nieto, Carlos | |
dc.contributor.author | Trinité, Benjamin | |
dc.contributor.author | Pradenas, Edwards | |
dc.contributor.author | Rodon, Jordi | |
dc.contributor.author | Marfil, Silvia | |
dc.contributor.author | Parera, Mariona | |
dc.contributor.author | Carrillo, Jorge | |
dc.contributor.author | Blanco, Julià | |
dc.contributor.author | Prado, Julia G. | |
dc.contributor.author | Ballana, Ester | |
dc.contributor.author | Vergara-Alert, Júlia | |
dc.contributor.author | Segalés, Joaquim | |
dc.contributor.author | Noguera-Julian, Marc | |
dc.contributor.author | Masabeu, Àngels | |
dc.contributor.author | Clotet, Bonaventura | |
dc.contributor.author | Toda, Maria de la Roca | |
dc.contributor.author | Paredes, Roger | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2022-01-27T15:32:58Z | |
dc.date.available | 2022-01-27T15:32:58Z | |
dc.date.issued | 2021-06-23 | |
dc.identifier.citation | Massanella, Marta, Anabel Martin-Urda, Lourdes Mateu, Toni Marín, Irene Aldas, Eva Riveira-Muñoz, and Athina Kipelainen et al. 2021. "Critical Presentation Of A Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection: A Case Report". Open Forum Infectious Diseases 8 (7). doi:10.1093/ofid/ofab329. | ca |
dc.identifier.issn | 2328-8957 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1582 | |
dc.description.abstract | Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections have been reported; however, most cases are milder than the primary infection. We report the first case of a life-threatening critical presentation of a SARS-CoV-2 reinfection. Methods: A 62-year-old man from Palamós (Spain) suffered a first mild coronavirus disease 2019 (COVID-19) episode in March 2020, confirmed by 2 independent SARS-CoV-2 nasopharyngeal polymerase chain reaction (PCR) assays and a normal radiograph. He recovered completely and tested negative on 2 consecutive PCRs. In August 2020, the patient developed a second SARS-CoV-2 infection with life-threatening bilateral pneumonia and Acute respiratory distress syndrome criteria, requiring COVID-19–specific treatment (remdesivir + dexamethasone) plus high-flow oxygen therapy. Nasopharyngeal swabs from the second episode were obtained for virus quantification by real-time PCR, for virus outgrowth and sequencing. In addition, plasma and peripheral blood mononuclear cells during the hospitalization period were used to determine SARS-CoV-2–specific humoral and T-cell responses. Results: Genomic analysis of SARS-CoV-2 showed that the virus had probably originated shortly before symptom onset. When the reinfection occurred, the subject showed a weak immune response, with marginal humoral and specific T-cell responses against SARS-CoV-2. All antibody isotypes tested as well as SARS-CoV-2 neutralizing antibodies increased sharply after day 8 postsymptoms. A slight increase of T-cell responses was observed at day 19 after symptom onset. Conclusions: The reinfection was firmly documented and occurred in the absence of robust preexisting humoral and cellular immunity. SARS-CoV-2 immunity in some subjects is unprotective and/or short-lived; therefore, SARS-CoV-2 vaccine schedules inducing long-term immunity will be required to bring the pandemic under control. | ca |
dc.format.extent | 6 | ca |
dc.language.iso | eng | ca |
dc.publisher | Oxford University Press | ca |
dc.relation.ispartof | Open Forum Infectious Diseases | ca |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.title | Critical Presentation of a Severe Acute Respiratory Syndrome Coronavirus 2 Reinfection: A Case Report | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1093/ofid/ofab329 | ca |
dc.contributor.group | Sanitat Animal | ca |
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