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Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms
dc.contributor.author | Gerkin, Richard C. | |
dc.contributor.author | Ohla, Kathrin | |
dc.contributor.author | Veldhuizen, Maria G. | |
dc.contributor.author | Joseph, Paule V. | |
dc.contributor.author | Kelly, Christine E. | |
dc.contributor.author | Bakke, Alyssa J. | |
dc.contributor.author | Steele, Kimberley E. | |
dc.contributor.author | Farruggia, Michael C. | |
dc.contributor.author | Pellegrino, Robert | |
dc.contributor.author | Pepino, Marta Y. | |
dc.contributor.author | Bouysset, Cédric | |
dc.contributor.author | Soler, Graciela M. | |
dc.contributor.author | Pereda-Loth, Veronica | |
dc.contributor.author | Dibattista, Michele | |
dc.contributor.author | Cooper, Keiland W. | |
dc.contributor.author | Croijmans, Ilja | |
dc.contributor.author | Di Pizio, Antonella | |
dc.contributor.author | Ozdener, M. Hakan | |
dc.contributor.author | Fjaeldstad, Alexander W. | |
dc.contributor.author | Lin, Cailu | |
dc.contributor.author | Sandell, Mari A. | |
dc.contributor.author | Singh, Preet B. | |
dc.contributor.author | Brindha, V. Evelyn | |
dc.contributor.author | Olsson, Shannon B. | |
dc.contributor.author | Saraiva, Luis R. | |
dc.contributor.author | Ahuja, Gaurav | |
dc.contributor.author | Alwashahi, Mohammed K. | |
dc.contributor.author | Bhutani, Surabhi | |
dc.contributor.author | D’Errico, Anna | |
dc.contributor.author | Fornazieri, Marco A. | |
dc.contributor.author | Golebiowski, Jérôme | |
dc.contributor.author | Hwang, Liang-Dar | |
dc.contributor.author | Öztürk, Lina | |
dc.contributor.author | Roura, Eugeni | |
dc.contributor.author | Spinelli, Sara | |
dc.contributor.author | Whitcroft, Katherine L. | |
dc.contributor.author | Guàrdia, Maria Dolors | |
dc.contributor.other | Indústries Alimentàries | ca |
dc.date.accessioned | 2022-03-31T09:20:10Z | |
dc.date.available | 2022-03-31T09:20:10Z | |
dc.date.issued | 2020-12-25 | |
dc.identifier.citation | Gerkin, Richard C, Kathrin Ohla, Maria G Veldhuizen, Paule V Joseph, Christine E Kelly, Alyssa J Bakke, and Kimberley E Steele et al. 2021. "Recent Smell Loss Is The Best Predictor Of COVID-19 Among Individuals With Recent Respiratory Symptoms". Chemical Senses 46. doi:10.1093/chemse/bjaa081. | ca |
dc.identifier.issn | 0379-864X | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1702 | |
dc.description.abstract | In a preregistered, cross-sectional study, we investigated whether olfactory loss is a reliable predictor of COVID-19 using a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0–100 visual analog scales (VAS) for participants reporting a positive (C19+; n = 4148) or negative (C19−; n = 546) COVID-19 laboratory test outcome. Logistic regression models identified univariate and multivariate predictors of COVID-19 status and post-COVID-19 olfactory recovery. Both C19+ and C19− groups exhibited smell loss, but it was significantly larger in C19+ participants (mean ± SD, C19+: −82.5 ± 27.2 points; C19−: −59.8 ± 37.7). Smell loss during illness was the best predictor of COVID-19 in both univariate and multivariate models (ROC AUC = 0.72). Additional variables provide negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms (e.g., fever). Olfactory recovery within 40 days of respiratory symptom onset was reported for ~50% of participants and was best predicted by time since respiratory symptom onset. We find that quantified smell loss is the best predictor of COVID-19 amongst those with symptoms of respiratory illness. To aid clinicians and contact tracers in identifying individuals with a high likelihood of having COVID-19, we propose a novel 0–10 scale to screen for recent olfactory loss, the ODoR-19. We find that numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4 < OR < 10). Once independently validated, this tool could be deployed when viral lab tests are impractical or unavailable. | ca |
dc.format.extent | 26 | ca |
dc.language.iso | eng | ca |
dc.publisher | Oxford University Press | ca |
dc.relation.ispartof | Chemical Senses | ca |
dc.rights | Copyright © The Author(s) 2020. Published by Oxford University Press. All rights reserved | ca |
dc.title | Recent Smell Loss Is the Best Predictor of COVID-19 Among Individuals With Recent Respiratory Symptoms | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/acceptedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | 12 mesos | ca |
dc.subject.udc | 663/664 | ca |
dc.identifier.doi | https://doi.org/10.1093/chemse/bjaa081 | ca |
dc.contributor.group | Qualitat i Tecnologia Alimentària | ca |
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