Complex Particulate Biomaterials as Immunostimulant-Delivery Platforms
The control of infectious diseases is a major current challenge in intensive aquaculture. Most commercial vaccines are based on live attenuated or inactivated pathogens that are usually combined with adjuvants, oil emulsions being as the most widely used for vaccination in aquaculture. Although effective, the use of these oil emulsions is plagued with important side effects. Thus, the development of alternative safer and cost-effective immunostimulants and adjuvants is highly desirable. Here we have explored the capacity of inclusion bodies produced in bacteria to immunostimulate and protect fish against bacterial infections. Bacterial inclusion bodies are highly stable, non-toxic protein-based biomaterials produced through fully scalable and low-cost bio-production processes. The present study shows that the composition and structured organization of inclusion body components (protein, lipopolysaccharide, peptidoglycan, DNA and RNA) make these protein biomaterials excellent immunomodulators able to generically protect fish against otherwise lethal bacterial challenges. The results obtained in this work provide evidence that their inherent nature makes bacterial inclusion bodies exceptionally attractive as immunostimulants and this opens the door to the future exploration of this biomaterial as an alternative adjuvant for vaccination purposes in veterinary.
619 - Veterinària
Public Library of Science
Is part of
Torrealba, Débora, Joaquin Seras-Franzoso, Uwe Mamat, Kathleen Wilke, Antonio Villaverde, Nerea Roher, and Elena Garcia-Fruitós. 2016. "Complex Particulate Biomaterials As Immunostimulant-Delivery Platforms". PLOS ONE 11 (10): e0164073. doi:10.1371/journal.pone.0164073.
Grant agreement number
MINECO/Programa Nacional de Proyectos de Investigación Fundamental/AGL2012-33877/ES/DESARROLLO DE NANOLIPOSOMAS COMO VEHICULOS DE INMUNOESTIMULANTES-VACUNAS EN ESPECIES DE INTERES PARA LA ACUICULTURA/
MINECOPrograma Nacional de Proyectos de Investigación Fundamental/RTA2012-00028-C02-02/ES/Optimización del periodo de secado de la vaca mediante nanopartículas proteicas/
MICINN/Programa Estatal de promoción del talento y su empleabilidad en I+D+I/RYC-2010-06210/ES/ /
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- ARTICLES CIENTÍFICS 
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