dc.contributor.author | Tarrés-Freixas, Ferran | |
dc.contributor.author | Trinité, Benjamin | |
dc.contributor.author | Pons-Grífols, Anna | |
dc.contributor.author | Romero-Durana, Miguel | |
dc.contributor.author | Riveira-Muñoz, Eva | |
dc.contributor.author | Ávila-Nieto, Carlos | |
dc.contributor.author | Pérez, Mónica | |
dc.contributor.author | Garcia-Vidal, Edurne | |
dc.contributor.author | Perez-Zsolt, Daniel | |
dc.contributor.author | Muñoz-Basagoiti, Jordana | |
dc.contributor.author | Raïch-Regué, Dàlia | |
dc.contributor.author | Izquierdo-Useros, Nuria | |
dc.contributor.author | Andrés, Cristina | |
dc.contributor.author | Antón, Andrés | |
dc.contributor.author | Pumarola, Tomàs | |
dc.contributor.author | Blanco, Ignacio | |
dc.contributor.author | Noguera-Julián, Marc | |
dc.contributor.author | Guallar, Victor | |
dc.contributor.author | Lepore, Rosalba | |
dc.contributor.author | Valencia, Alfonso | |
dc.contributor.author | Urrea, Victor | |
dc.contributor.author | Vergara-Alert, Júlia | |
dc.contributor.author | Clotet, Bonaventura | |
dc.contributor.author | Ballana, Ester | |
dc.contributor.author | Carrillo, Jorge | |
dc.contributor.author | Segalés, Joaquim | |
dc.contributor.author | Blanco, Julià | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2022-07-29T08:31:50Z | |
dc.date.available | 2022-07-29T08:31:50Z | |
dc.date.issued | 2022-05-04 | |
dc.identifier.citation | Tarrés-Freixas, Ferran, Benjamin Trinité, Anna Pons-Grífols, Miguel Romero-Durana, Eva Riveira-Muñoz, Carlos Ávila-Nieto, Mónica Pérez, Edurne Garcia-Vidal, Daniel Perez-Zsolt, Jordana Muñoz-Basagoiti, Dàlia Raïch-Regué, Nuria Izquierdo-Useros, Cristina Andrés, Andrés Antón, Tomàs Pumarola, Ignacio Blanco, Marc Noguera-Julián, Victor Guallar, Rosalba Lepore, Alfonso Valencia, Victor Urrea, Júlia Vergara-Alert, Bonaventura Clotet, Ester Ballana, Jorge Carrillo, Joaquim Segalés, Julià Blanco. 2022. "Heterogeneous Infectivity And Pathogenesis Of SARS-Cov-2 Variants Beta, Delta And Omicron In Transgenic K18-Hace2 And Wildtype Mice". Frontiers In Microbiology 13. doi:10.3389/fmicb.2022.840757. | ca |
dc.identifier.issn | 1664-302X | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1813 | |
dc.description.abstract | The emerging SARS-CoV-2 variants of concern (VOCs) may display enhanced transmissibility, more severity and/or immune evasion; however, the pathogenesis of these new VOCs in experimental SARS-CoV-2 models or the potential infection of other animal species is not completely understood. Here we infected K18-hACE2 transgenic mice with B.1, B.1.351/Beta, B.1.617.2/Delta and BA.1.1/Omicron isolates and demonstrated heterogeneous infectivity and pathogenesis. B.1.351/Beta variant was the most pathogenic, while BA.1.1/Omicron led to lower viral RNA in the absence of major visible clinical signs. In parallel, we infected wildtype (WT) mice and confirmed that, contrary to B.1 and B.1.617.2/Delta, B.1.351/Beta and BA.1.1/Omicron can infect them. Infection in WT mice coursed without major clinical signs and viral RNA was transient and undetectable in the lungs by day 7 post-infection. In silico modeling supported these findings by predicting B.1.351/Beta receptor binding domain (RBD) mutations result in an increased affinity for both human and murine ACE2 receptors, while BA.1/Omicron RBD mutations only show increased affinity for murine ACE2. | ca |
dc.format.extent | 13 | ca |
dc.language.iso | eng | ca |
dc.publisher | Frontiers Media | ca |
dc.relation.ispartof | Frontiers in Microbiology | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Heterogeneous Infectivity and Pathogenesis of SARS-CoV-2 Variants Beta, Delta and Omicron in Transgenic K18-hACE2 and Wildtype Mice | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.3389/fmicb.2022.840757 | ca |
dc.contributor.group | Sanitat Animal | ca |