dc.contributor.author | Cano-Garrido, Olivia | |
dc.contributor.author | Céspedes, María Virtudes | |
dc.contributor.author | Unzueta, Ugutz | |
dc.contributor.author | Saccardo, Paolo | |
dc.contributor.author | Roldán, Mònica | |
dc.contributor.author | Sánchez-Chardi, Alejandro | |
dc.contributor.author | Cubarsi, Rafael | |
dc.contributor.author | Vázquez, Esther | |
dc.contributor.author | Mangues, Ramon | |
dc.contributor.author | García-Fruitós, Elena | |
dc.contributor.author | Villaverde, Antonio | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2022-08-02T12:26:15Z | |
dc.date.available | 2022-08-02T12:26:15Z | |
dc.date.issued | 2016-08-16 | |
dc.identifier.citation | Cano-Garrido, Olivia, María Virtudes Céspedes, Ugutz Unzueta, Paolo Saccardo, Mònica Roldán, Alejandro Sánchez-Chardi, Rafael Cubarsi, Esther Vázquez, Ramon Mangues, Elena García-Fruitós and Antonio Villaverde. 2016. "CXCR4+-Targeted Protein Nanoparticles Produced In The Food-Grade Bacterium Lactococcus Lactis | Nanomedicine". Nanomedicine 11 (18): 2387-2398. https://www.futuremedicine.com/doi/10.2217/nnm-2016-0200. | ca |
dc.identifier.issn | 1743-5889 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1844 | |
dc.description.abstract | Aim: Lactococcus lactis is a Gram-positive (endotoxin-free) food-grade bacteria exploited as alternative to Escherichia coli for recombinant protein production. We have explored here for the first time the ability of this platform as producer of complex, self-assembling protein materials. Materials & methods: Biophysical properties, cell penetrability and in vivo biodistribution upon systemic administration of tumor-targeted protein nanoparticles produced in L. lactis have been compared with the equivalent material produced in E. coli. Results: Protein nanoparticles have been efficiently produced in L. lactis, showing the desired size, internalization properties and biodistribution. Conclusion: In vitro and in vivo data confirm the potential and robustness of the production platform, pointing out L. lactis as a fascinating cell factory for the biofabrication of protein materials intended for therapeutic applications. | ca |
dc.format.extent | 12 | ca |
dc.language.iso | eng | ca |
dc.publisher | Future Science Group | ca |
dc.relation.ispartof | Nanomedicine | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | CXCR4+-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | MINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/BIO2013-41019-P/ES/INGENIERIA DE NANOPARTICULAS PROTEICAS PARA LA ENTREGA DIRIGIDA DE PROTEINAS TERAPEUTICAS Y DE ACIDOS NUCLEICOS/ | ca |
dc.relation.projectID | ISCIII/Programa Estatal de I+D+I orientada a los retos de la sociedad/PI15-00272/ES/Diseño de nanoconjugados inteligentes para el tratamiento del cáncer colorrectal metastásico/ | ca |
dc.subject.udc | 61 | ca |
dc.identifier.doi | https://doi.org/10.2217/nnm-2016-0200 | ca |
dc.contributor.group | Producció de Remugants | ca |