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dc.contributor.authorCano-Garrido, Olivia
dc.contributor.authorCéspedes, María Virtudes
dc.contributor.authorUnzueta, Ugutz
dc.contributor.authorSaccardo, Paolo
dc.contributor.authorRoldán, Mònica
dc.contributor.authorSánchez-Chardi, Alejandro
dc.contributor.authorCubarsi, Rafael
dc.contributor.authorVázquez, Esther
dc.contributor.authorMangues, Ramon
dc.contributor.authorGarcía-Fruitós, Elena
dc.contributor.authorVillaverde, Antonio
dc.contributor.otherProducció Animalca
dc.date.accessioned2022-08-02T12:26:15Z
dc.date.available2022-08-02T12:26:15Z
dc.date.issued2016-08-16
dc.identifier.citationCano-Garrido, Olivia, María Virtudes Céspedes, Ugutz Unzueta, Paolo Saccardo, Mònica Roldán, Alejandro Sánchez-Chardi, Rafael Cubarsi, Esther Vázquez, Ramon Mangues, Elena García-Fruitós and Antonio Villaverde. 2016. "CXCR4+-Targeted Protein Nanoparticles Produced In The Food-Grade Bacterium Lactococcus Lactis | Nanomedicine". Nanomedicine 11 (18): 2387-2398. https://www.futuremedicine.com/doi/10.2217/nnm-2016-0200.ca
dc.identifier.issn1743-5889ca
dc.identifier.urihttp://hdl.handle.net/20.500.12327/1844
dc.description.abstractAim: Lactococcus lactis is a Gram-positive (endotoxin-free) food-grade bacteria exploited as alternative to Escherichia coli for recombinant protein production. We have explored here for the first time the ability of this platform as producer of complex, self-assembling protein materials. Materials & methods: Biophysical properties, cell penetrability and in vivo biodistribution upon systemic administration of tumor-targeted protein nanoparticles produced in L. lactis have been compared with the equivalent material produced in E. coli. Results: Protein nanoparticles have been efficiently produced in L. lactis, showing the desired size, internalization properties and biodistribution. Conclusion: In vitro and in vivo data confirm the potential and robustness of the production platform, pointing out L. lactis as a fascinating cell factory for the biofabrication of protein materials intended for therapeutic applications.ca
dc.format.extent12ca
dc.language.isoengca
dc.publisherFuture Science Groupca
dc.relation.ispartofNanomedicineca
dc.rightsAttribution 4.0 Internationalca
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleCXCR4+-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactisca
dc.typeinfo:eu-repo/semantics/articleca
dc.description.versioninfo:eu-repo/semantics/publishedVersionca
dc.rights.accessLevelinfo:eu-repo/semantics/openAccess
dc.embargo.termscapca
dc.relation.projectIDMINECO/Programa Estatal de fomento de la investigación científica y técnica de excelencia/BIO2013-41019-P/ES/INGENIERIA DE NANOPARTICULAS PROTEICAS PARA LA ENTREGA DIRIGIDA DE PROTEINAS TERAPEUTICAS Y DE ACIDOS NUCLEICOS/ca
dc.relation.projectIDISCIII/Programa Estatal de I+D+I orientada a los retos de la sociedad/PI15-00272/ES/Diseño de nanoconjugados inteligentes para el tratamiento del cáncer colorrectal metastásico/ca
dc.subject.udc61ca
dc.identifier.doihttps://doi.org/10.2217/nnm-2016-0200ca
dc.contributor.groupProducció de Remugantsca


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Attribution 4.0 International
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/
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