dc.contributor.author | Ainsua-Enrich, Erola | |
dc.contributor.author | Pedreño-Lopez, Núria | |
dc.contributor.author | Bracke, Carmen | |
dc.contributor.author | Ávila-Nieto, Carlos | |
dc.contributor.author | Rodríguez de la Concepción, María Luisa | |
dc.contributor.author | Pradenas, Edwards | |
dc.contributor.author | Trinité, Benjamin | |
dc.contributor.author | Marfil, Silvia | |
dc.contributor.author | Miranda, Cristina | |
dc.contributor.author | González, Sandra | |
dc.contributor.author | Toledo, Ruth | |
dc.contributor.author | Font, Marta | |
dc.contributor.author | Benet, Susana | |
dc.contributor.author | Escribà, Tuixent | |
dc.contributor.author | Jimenez-Moyano, Esther | |
dc.contributor.author | Peña, Ruth | |
dc.contributor.author | Cedeño, Samandhy | |
dc.contributor.author | Prado, Julia G. | |
dc.contributor.author | Mothe, Beatriz | |
dc.contributor.author | Brander, Christian | |
dc.contributor.author | Izquierdo-Useros, Nuria | |
dc.contributor.author | Vergara-Alert, Júlia | |
dc.contributor.author | Segalés, Joaquim | |
dc.contributor.author | Massanella, Marta | |
dc.contributor.author | Benitez, Rosa María | |
dc.contributor.author | Romero, Alba | |
dc.contributor.author | Molina-Morant, Daniel | |
dc.contributor.author | Blanco, Julià | |
dc.contributor.author | Clotet, Bonaventura | |
dc.contributor.author | Mateu, Lourdes | |
dc.contributor.author | Pedro-Botet, María Luisa | |
dc.contributor.author | Carrillo, Jorge | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2022-12-22T15:07:57Z | |
dc.date.available | 2022-12-22T15:07:57Z | |
dc.date.issued | 2022-10-28 | |
dc.identifier.citation | Ainsua-Enrich, Erola, Núria Pedreño-Lopez, Carmen Bracke, Carlos Ávila-Nieto, María Luisa Rodríguez de la Concepción, Edwards Pradenas, and Benjamin Trinité et al. 2022. "Kinetics Of Immune Responses Elicited After Three Mrna COVID-19 Vaccine Doses In Predominantly Antibody-Deficient Individuals". Iscience 25 (11): 105455. doi:10.1016/j.isci.2022.105455. | ca |
dc.identifier.issn | 2589-0042 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/1985 | |
dc.description.abstract | Mass vaccination campaigns reduced COVID-19 incidence and severity. Here, we evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies (PAD) after three mRNA-1273 vaccine doses. PAD patients were classified based on their immunodeficiency: unclassified primary antibody-deficiency (unPAD, n = 9), common variable immunodeficiency (CVID, n = 12), combined immunodeficiency (CID, n = 1), and thymoma with immunodeficiency (TID, n = 1). unPAD patients and healthy controls (HCs, n = 10) developed similar vaccine-induced humoral responses after two doses. However, CVID patients showed reduced binding and neutralizing titers compared to HCs. Of interest, these PAD groups showed lower levels of Spike-specific IFN-γ-producing cells. CVID individuals also presented diminished CD8+T cells. CID and TID patients developed cellular but not humoral responses. Although the third vaccine dose boosted humoral responses in most PAD patients, it had limited effect on expanding cellular immunity. Vaccine-induced immune responses in PAD individuals are heterogeneous, and should be immunomonitored to define a personalized therapeutic strategies. | ca |
dc.format.extent | 19 | ca |
dc.language.iso | eng | ca |
dc.publisher | Cell Press | ca |
dc.relation.ispartof | iScience | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Kinetics of immune responses elicited after three mRNA COVID-19 vaccine doses in predominantly antibody-deficient individuals | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | ISCII/Programa Estatal de fomento de la investigación científica y técnica de excelencia/PI17-01518/Desarrollo de una plataforma de vacunas contra el VIH basada en partículas similares a virus (VLP) envueltas y de alta densidad antigénica/ | ca |
dc.relation.projectID | ISCII/Programa Estatal de fomento de la investigación científica y técnica de excelencia/PI18-01332/ES/Identificación, aislamiento y caracterización de anticuerpos que interfieren con la acción de los anticuerpos neutralizantes en personas infectadas por el virus de la inmunodeficiencia humana/ | ca |
dc.relation.projectID | MC/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2020-119710RB-I00/ES/La cascada epigenética de infecciones virales neurotrópicas/ | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1016/j.isci.2022.105455 | ca |
dc.contributor.group | Sanitat Animal | ca |