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XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
dc.contributor.author | Domenjo-Vila, Eva | |
dc.contributor.author | Casella, Valentina | |
dc.contributor.author | Iwabuchi, Ryutaro | |
dc.contributor.author | Fossum, Even | |
dc.contributor.author | Pedragosa, Mireia | |
dc.contributor.author | Castellví, Quim | |
dc.contributor.author | Cebollada Rica, Paula | |
dc.contributor.author | Kaisho, Tsuneyasu | |
dc.contributor.author | Terahara, Kazutaka | |
dc.contributor.author | Bocharov, Gennady | |
dc.contributor.author | Argilaguet, Jordi | |
dc.contributor.author | Meyerhans, Andreas | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2023-02-23T17:45:33Z | |
dc.date.available | 2023-02-23T17:45:33Z | |
dc.date.issued | 2023-02-14 | |
dc.identifier.citation | Domenjo-Vila, Eva, Valentina Casella, Ryutaro Iwabuchi, Even Fossum, Mireia Pedragosa, Quim Castellví, Paula Cebollada Rica, Tsuneyasu Kaisho, Kazutaka Terahara, Gennady Bocharov, Jordi Argilaguet, and Andreas Meyerhans. (2023). XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections. Cell Reports, 42(2), 112123. doi: 10.1016/j.celrep.2023.112123 | ca |
dc.identifier.issn | 2211-1247 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/2120 | |
dc.description.abstract | The contribution of cross-presenting XCR1+ dendritic cells (DCs) and SIRPα+ DCs in maintaining T cell function during exhaustion and immunotherapeutic interventions of chronic infections remains poorly characterized. Using the mouse model of chronic LCMV infection, we found that XCR1+ DCs are more resistant to infection and highly activated compared with SIRPα+ DCs. Exploiting XCR1+ DCs via Flt3L-mediated expansion or XCR1-targeted vaccination notably reinvigorates CD8+ T cells and improves virus control. Upon PD-L1 blockade, XCR1+ DCs are not required for the proliferative burst of progenitor exhausted CD8+ T (TPEX) cells but are indispensable to sustain the functionality of exhausted CD8+ T (TEX) cells. Combining anti-PD-L1 therapy with increased frequency of XCR1+ DCs improves functionality of TPEX and TEX subsets, while increase of SIRPα+ DCs dampened their proliferation. Together, this demonstrates that XCR1+ DCs are crucial for the success of checkpoint inhibitor-based therapies through differential activation of exhausted CD8+ T cell subsets. | ca |
dc.format.extent | 29 | ca |
dc.language.iso | eng | ca |
dc.publisher | Cell Press | ca |
dc.relation.ispartof | Cell Reports | ca |
dc.rights | Attribution 4.0 International | ca |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | MICIU-FEDER/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I y Programa Estatal de I+D+I orientada a los retos de la sociedad/PID2019-106323RB-I00/ES/Characterization and manipulation of control points of virus infection fates/ | ca |
dc.relation.projectID | MICIU/Programa Estatal de generación del conocimiento y fortalecimiento científico y tecnológico del sistema I+D+I/CEX2018-000792-M/ES/ / | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1016/j.celrep.2023.112123 | ca |
dc.contributor.group | Sanitat Animal | ca |
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