Emergence and clonal expansion of Vibrio aestuarianus lineages pathogenic for oysters in Europe
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Author
Mesnil, Aurélie
Jacquot, Maude
Garcia, Céline
Tourbiez, Delphine
Canier, Lydie
Bidois, Audrey
Dégremont, Lionel
Cheslett, Deborah
Geary, Michelle
Vetri, Alessia
Garden, Alison
Orozova, Petya
Arzul, Isabelle
Sicard, Mathieu
Charrière, Guillaume M.
Destoumieux-Garzón, Delphine
Travers, Marie-Agnès
Publication date
2023-03-01ISSN
0962-1083
Abstract
Crassostrea gigas oysters represent a significant global food source with 4.7 million tons harvested per year. In 2001, the bacterium Vibrio aestuarianus subsp. francensis emerged as a pathogen that causes adult oyster mortality in France and Ireland. Its impact on oyster aquaculture has increased in Europe since its re-emergence in 2012. To better understand the evolutionary mechanisms leading to the emergence and persistence over time of this pathogen, we conducted a survey of mollusc diseases through national reference laboratories across Europe. We analysed 54 new genomes of Vibrio aestuarianus (Va) isolated from multiple environmental compartments since 2001, in areas with and without bivalve mortalities. We used a combination of comparative genomics and population genetics approaches and show that Va has a classical epidemic population structure from which the pathogenic Va francensis subspecies emerged and clonally expanded. Furthermore, we identified a specific cus-cop-containing island conferring copper resistance to Va francensis whose acquisition may have favoured the emergence of pathogenic lineages adapted and specialized to oysters.
Document Type
Article
Document version
Accepted version
Language
English
Subject (CDU)
637 - Produce of domestic (farmyard) animals and game
Pages
35
Publisher
Wiley
Is part of
Molecular Ecology
Citation
Mesnil, Aurélie, Maude Jacquot, Céline Garcia, Delphine Tourbiez, Lydie Canier, Audrey Bidois, Lionel Dégremont, Deborah Cheslett, Michelle Geary, Alessia Vetri, Ana Roque, Dolors Furones, Alison Garden, Petya Orozova, Isabelle Arzul, Mathieu Sicard, Guillaume M. Charrière, Delphine Destoumieux-Garzón, Marie-Agnès Travers. 2023. “Emergence and clonal expansion of Vibrio aestuarianus lineages pathogenic for oysters in Europe”. Molecular Ecology. doi:10.1111/mec.16910
Grant agreement number
SANTE///EU//
Program
Aqüicultura
This item appears in the following Collection(s)
- ARTICLES CIENTÍFICS [2555]
Rights
© 2023 Crown copyright. Molecular Ecology © 2023 John Wiley & Sons Ltd.