Evaluation of the capability of the PCV2 genome to encode miRNAs: lack of viral miRNA expression in an experimental infection
Pérez, Lester J.
Núñez, José I.
Porcine circovirus type 2 (PCV2) is a ssDNA virus causing PCV2-systemic disease (PCV2-SD), one of the most important diseases in swine. MicroRNAs (miRNAs) are a new class of small non-coding RNAs that regulate gene expression post-transcriptionally. Viral miRNAs have recently been described and the number of viral miRNAs has been increasing in the past few years. In this study, small RNA libraries were constructed from two tissues of subclinically PCV2 infected pigs to explore if PCV2 can encode viral miRNAs. The deep sequencing data revealed that PCV2 does not express miRNAs in an in vivo subclinical infection.
619 - Veterinary science
Is part of
Núñez-Hernández, F., Pérez, L. J., Vera, G., Córdoba, S., Segalés, J., Sánchez, A. and Núñez, J. I. Núñez-Hernández, Fernando, Lester J Pérez, Gonzalo Vera, Sarai Córdoba, Joaquim Segalés, Armand Sánchez, and José I Núñez. 2015. "Evaluation Of The Capability Of The PCV2 Genome To Encode Mirnas: Lack Of Viral Mirna Expression In An Experimental Infection". Veterinary Research 46 (1). doi:10.1186/s13567-015-0181-4.
Grant agreement number
MEC/ /AGL2007-66371-C02/ES/IDENTIFICACION Y CARACTERIZACION DE MICRORNAS VIRICOS QUE AFECTAN AL PORCINO/
MICINN/Programa Nacional de Proyectos de Investigación Fundamental/AGL2010-22358-C02-02/ES/MICRORNAS EN INFECCIONES VIRICAS DEL CERDO: ANALISIS FUNCIONAL E IMPLICACIONES EN PATOGENIA VIRAL/
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- ARTICLES CIENTÍFICS 
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