dc.contributor.author | Rodriguez, Ariel | |
dc.contributor.author | Falcon, Ana | |
dc.contributor.author | Cuevas, Maria Teresa | |
dc.contributor.author | Pozo, Francisco | |
dc.contributor.author | Guerra, Susana | |
dc.contributor.author | García-Barreno, Blanca | |
dc.contributor.author | Martinez-Orellana, Pamela | |
dc.contributor.author | Pérez-Breña, Pilar | |
dc.contributor.author | Montoya, Maria | |
dc.contributor.author | Melero, Jose Antonio | |
dc.contributor.author | Ortin, Juan | |
dc.contributor.author | Casas, Inmaculada | |
dc.contributor.author | Nieto, Amelia | |
dc.contributor.other | Producció Animal | ca |
dc.date.accessioned | 2023-06-07T09:43:10Z | |
dc.date.available | 2023-06-07T09:43:10Z | |
dc.date.issued | 2013-01-10 | |
dc.identifier.citation | Rodriguez, Ariel, Ana Falcon, Maria Teresa Cuevas, Francisco Pozo, Susana Guerra, Blanca García-Barreno, and Pamela Martinez-Orellana et al. 2013. "Characterization In Vitro And In Vivo Of A Pandemic H1N1 Influenza Virus From A Fatal Case". Plos ONE 8 (1): e53515. doi:10.1371/journal.pone.0053515. | ca |
dc.identifier.issn | 1932-6203 | ca |
dc.identifier.uri | http://hdl.handle.net/20.500.12327/2256 | |
dc.description.abstract | Pandemic 2009 H1N1 (pH1N1) influenza viruses caused mild symptoms in most infected patients. However, a greater rate of severe disease was observed in healthy young adults and children without co-morbid conditions. Here we tested whether influenza strains displaying differential virulence could be present among circulating pH1N1 viruses. The biological properties and the genotype of viruses isolated from a patient showing mild disease (M) or from a fatal case (F), both without known co-morbid conditions were compared in vitro and in vivo. The F virus presented faster growth kinetics and stronger induction of cytokines than M virus in human alveolar lung epithelial cells. In the murine model in vivo, the F virus
showed a stronger morbidity and mortality than M virus. Remarkably, a higher proportion of mice presenting infectious virus in the hearts, was found in F virus-infected animals. Altogether, the data indicate that strains of pH1N1 virus with enhanced pathogenicity circulated during the 2009 pandemic. In addition, examination of chemokine receptor 5 (CCR5) genotype, recently reported as involved in severe influenza virus disease, revealed that the F virus-infected patient was homozygous for the deleted form of CCR5 receptor (CCR5D32) | ca |
dc.format.extent | 12 | ca |
dc.language.iso | eng | ca |
dc.publisher | Public Library of Science | ca |
dc.relation.ispartof | PLoS ONE | ca |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Characterization In Vitro and In Vivo of a Pandemic H1N1 Influenza Virus from a Fatal Case | ca |
dc.type | info:eu-repo/semantics/article | ca |
dc.description.version | info:eu-repo/semantics/publishedVersion | ca |
dc.rights.accessLevel | info:eu-repo/semantics/openAccess | |
dc.embargo.terms | cap | ca |
dc.relation.projectID | ISCIII/Programa especial de investigación sobre la gripe pándemica/GR09-0023/ES/ / | ca |
dc.relation.projectID | ISCIII/Programa especial de investigación sobre la gripe pándemica/GR09-0039/ES/ / | ca |
dc.relation.projectID | ISCIII/Programa especial de investigación sobre la gripe pándemica/GR09-0040/ES/ / | ca |
dc.relation.projectID | ISCIII/ /CIBER/ES/Enfermedades Infecciosas/ | ca |
dc.subject.udc | 578 | ca |
dc.subject.udc | 619 | ca |
dc.identifier.doi | https://doi.org/10.1371/journal.pone.0053515 | ca |
dc.contributor.group | Sanitat Animal | ca |